SynthesisFrontiers in medicine2026
Global trajectories of polygenic risk score research: a systematic bibliometric review of precision medicine, equity, and clinical translation.
Synthesis in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Introduction: Polygenic risk scores (PRS) have emerged as a central tool in genomic medicine, enabling risk prediction for common, complex diseases. Despite rapid methodological and clinical advances, concerns remain regarding the structural organization of PRS research, including geographic concentration, funding dominance, and limited global representation. A systematic, field-level assessment of PRS research evolution is needed to inform equitable and sustainable translation. Methods: We conducted a systematic bibliometric review of PRS research published between 1999 and 2024, using the Web of Science Core Collection to map publication growth, geographic and institutional contributions, funding patterns, collaboration networks, and thematic evolution. Results: The final dataset comprised 10,269 PRS-related publications across 2,185 sources, exhibiting a strong annual growth rate of 21.56%. Publication output accelerated markedly after 2017, reaching 1,580 articles in 2024. Logistic modeling demonstrated an excellent fit ( Conclusion: PRS research has evolved into a mature, high-volume field with expanding clinical relevance, yet remains structurally concentrated in terms of geography, institutions, and funding. While bibliometric analyses do not directly reflect the ancestry composition of study populations, the observed concentration patterns highlight the importance of continued efforts toward broad collaboration, diversified funding landscapes, and transparent reporting practices to support globally representative and clinically robust implementation of PRS in precision medicine.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.