Evidence map›Paper›PMID 42023113›Full record

ArticleFrontiers in medicine2026

Kerui Wu, Yan Ran, Zinuo Chen, Chenglong Chen, Xuran Gu, Qinghua Cui, Ruikun Du

Abstract read
In one paragraph

Article in Frontiers in medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kerui Wu *Qingdao Academy of Chinese Medical Sciences, Shandong University of Traditional Chinese Medicine, Qingdao, China.
Yan Ran *Qingdao Academy of Chinese Medical Sciences, Shandong University of Traditional Chinese Medicine, Qingdao, China.
Zinuo ChenQingdao Academy of Chinese Medical Sciences, Shandong University of Traditional Chinese Medicine, Qingdao, China.
Chenglong ChenQingdao Academy of Chinese Medical Sciences, Shandong University of Traditional Chinese Medicine, Qingdao, China.
Xuran GuQingdao Academy of Chinese Medical Sciences, Shandong University of Traditional Chinese Medicine, Qingdao, China.
Qinghua CuiQingdao Academy of Chinese Medical Sciences, Shandong University of Traditional Chinese Medicine, Qingdao, China.
Ruikun DuQingdao Academy of Chinese Medical Sciences, Shandong University of Traditional Chinese Medicine, Qingdao, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The innate immunity of host defends universally against various invading viruses, providing attractive targets for development of novel broad-spectrum antivirals. However, the antiviral innate immunity usually has "double-edged sword" effects, and clinical applications of either innate immune enhancers or suppressors depend highly on the timing of administration, which requires precision diagnosis and careful evaluation of the disease status. Irrational use of a single-directional immune modulator may greatly compromise the efficacy or even cause more severe diseases. The bi-directional modulators can balance the protective-vs.-detrimental effects of antiviral innate immunities, showing expanded "window of therapeutic opportunity" and advanced translational potency. Previously, we identified the potential bi-directional immune modulatory effect of

Indexed as

antiviral innate immunitybi-directional immune modulationbroad-spectrum antiviralChinese herbal medicineScutellaria barbata D. Don

Identifiers

PMID42023113
PMCPMC13095528

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.