ArticleApplied sciences (Basel, Switzerland)2026
Hexavalent Chromium Oropharyngeal Aspiration Induced Behavior Effects and Essential Metal Dyshomeostasis in Young Hartley Guinea Pigs.
Samuel T Vielee, Idoia Meaza, William J Buchanan, Spencer H Roof, Haiyan Lu, Sandra S Diven, Luping Guo, Jack Easley, J Calvin Kouokam, Jamie Lynn Wise and 3 more
Abstract read
In one paragraphArticle in Applied sciences (Basel, Switzerland), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
2 · The registryThe trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
3 · Its place in the literatureWho cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
4 · The recordCorrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
5 · Who and what moneyAuthors and funding
13 authors.
Samuel T VieleeDepartment of Pediatrics, University of Louisville, Louisville, KY 40292, USA.
Idoia MeazaDepartment of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40292, USA.ORCID 0000-0001-5292-0843 William J BuchananDepartment of Pediatrics, University of Louisville, Louisville, KY 40292, USA.
Spencer H RoofDepartment of Pediatrics, University of Louisville, Louisville, KY 40292, USA.
Haiyan LuDepartment of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40292, USA.ORCID 0000-0002-6711-0314 Sandra S DivenDepartment of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40292, USA.
Luping GuoDepartment of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40292, USA.
Jack EasleyDepartment of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40292, USA.ORCID 0009-0000-4964-1499 J Calvin KouokamDepartment of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40292, USA.ORCID 0000-0001-8679-2536 Jamie Lynn WiseDepartment of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40292, USA.
Aggie R BrownellDepartment of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40292, USA.ORCID 0000-0001-5840-1585 John Pierce WiseDepartment of Pharmacology and Toxicology, University of Louisville, Louisville, KY 40292, USA.
John P WiseDepartment of Pharmacology and Experimental Therapeutics, University of Toledo, 3100 Transverse Dr., Health Education Building Room 282C, Toledo, OH 43614, USA.ORCID 0000-0002-9416-8570 Funding
University of Louisville Center for Integrative Environmental Health SciencesP30ES030283 · NIEHS · UNIVERSITY OF LOUISVILLE · PI J CHRISTOPHER STATES · 2020 to 2026
$10.0MUOFL ENVIRONMENTAL HEALTH SCIENCES TRAINING PROGRAMT32ES011564 · NIEHS · UNIVERSITY OF LOUISVILLE · PI David W Hein, John Pierce Wise · 2004 to 2026
$7.1MChromosome Instability Drives Metal-Induced Lung CancerR35ES032876 · NIEHS · UNIVERSITY OF LOUISVILLE · PI John Pierce Wise · 2021 to 2026
$6.1MCr(VI)-Induced DNA Damage Contributes to Brain AgingR21ES033327 · NIEHS · UNIVERSITY OF LOUISVILLE · PI WISE, JOHN PIERCE · 2021 to 2022
$430kNIEHS NIH HHS P30 ES030283NIEHS NIH HHS R21 ES033327NIEHS NIH HHS R35 ES032876NIEHS NIH HHS T32 ES011564
6 · The paper itselfAbstract
Hexavalent chromium [Cr(VI)] is the toxic form of chromium often used in industry for its hardness, bright colors, and anticorrosive properties. Cr(VI) is a known human lung carcinogen, making its inhalation an occupational hazard. Growing evidence emphasizes the neurotoxic potential of Cr(VI), though it is not linked to brain cancers. Few studies consider neurotoxicity in chromate workers, reporting impaired olfactory discrimination and an increased risk of death from mental health disorders. A major factor limiting translation of most rodent Cr(VI) studies to human populations has to do with vitamin C, which can reduce the toxic Cr(VI) to non-toxic Cr(III). Rats and mice synthesize vitamin C and are likely more resistant to Cr(VI) than humans. Here, we considered Cr(VI) neurotoxicity in guinea pigs (
Indexed as
behavior effectsguinea pigshexavalent chromiuminhalation exposuremetallomicsneurotoxicitysex differences
Identifiers
PMID42023055
PMCPMC13099238
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