Evidence map›Paper›PMID 42023035›Full record

ArticleJournal of oral microbiology2026

Investigating oral microbiome profiles of children with cleft lip and palate in different states of caries.

Zhelin Shi, Yuehua Zhang, Yang Chen, Siying Wu, Zhuojun Zhou, Zhenqi Chen

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Article in Journal of oral microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Zhelin ShiDepartment of Orthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Yuehua ZhangDepartment of Stomatology, Shanghai East Hospital, School of Medicine, Tongji University, Shanghai, China.
Yang ChenCollege of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai, China.
Siying WuDepartment of Orthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.
Zhuojun ZhouCollege of Stomatology, Shanghai Jiao Tong University, National Center for Stomatology, National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology, Shanghai Research Institute of Stomatology, Shanghai, China.
Zhenqi ChenDepartment of Orthodontics, Shanghai Ninth People's Hospital, Shanghai Jiao Tong University, School of Medicine, Shanghai, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate the characteristics of oral salivary microbiota in children with cleft lip and palate (CLP) under different states of caries. Methods: Based on the presence or absence of CLP and the total number of decayed, missing and filled surfaces, 105 participants were divided into four groups: children with CLP and high caries (CLP-HC), children with CLP and low caries (CLP-LC), children without CLP but with high caries (NCLP-HC) and children without CLP but with low caries (NCLP-LC). Saliva samples from them were analyzed using 16S rRNA gene sequencing. Results: Alpha diversity differed significantly among the four groups with Ace and Chao indices, but not with Shannon and Simpson. Principal coordinate analysis based on the Weighted-UniFrac distance matrix showed no significant differences among the four groups, while results from the Unweighted-UniFrac distance matrix revealed significant differences. CLP-HC and CLP-LC had significantly higher Microbial Dysbiosis Index than NCLP-LC. LEfSe analysis was performed for pairwise comparisons, identifying differentially enriched bacterial genera among groups. Network analysis based on Spearman correlation revealed the interaction characteristics of microbial communities in different groups. Conclusions: Differences in microbial features were observed among the four groups, which could provide new insights for personalized oral health management for CLP patients.

Indexed as

16S rRNA sequencingCleft lip and palatedifferent states of cariesmicrobial diversityoral microbiotasaliva

Identifiers

PMID42023035
PMCPMC13097181

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