ArticleRSC advances2026
TAPP-based fluorescent probes for selective cysteine detection: insights into structure-reactivity relationships.
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Herein, a series of TAPP-based π-conjugated fluorescent probes functionalized with aldehyde, malononitrile, and cyanoacrylate groups were designed and synthesized to investigate structure-reactivity relationships in cysteine (Cys) sensing. The photophysical properties of the probes were systematically examined in THF, DCM, and DMSO. The results revealed that the absorption and emission features are primarily governed by π-π* transitions localized on the TAPP framework, while the terminal acceptor groups mainly modulate the electronic distribution without significantly altering the ground-state transitions. Among the investigated derivatives, only the aldehyde-functionalized probe exhibited a pronounced "turn-on" fluorescence response toward Cys. This behavior is attributed to a reaction-based sensing mechanism involving the formation of a thiazolidine ring between the aldehyde group and Cys. The proposed mechanism is supported by complementary spectroscopic analyses, including
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