ArticleRSC advances2026
A sustainable spectrofluorimetric method for ivabradine quantification based on erythrosin B quenching with quantum mechanical modeling and Box-Behnken design optimization.
Article in RSC advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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1 citing paper in PubMed.
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8 authors.
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Abstract
A novel, sensitive, and environmentally sustainable spectrofluorimetric method was developed for ivabradine determination based on the fluorescence quenching of erythrosin B. The method exploits the formation of a stable 1 : 1 ground-state complex between anionic erythrosin B and cationic ivabradine through electrostatic interactions. To elucidate the interaction mechanism, comprehensive mechanistic studies using Stern-Volmer analysis, thermodynamic parameters determination, and Job's method confirmed static quenching with spontaneous complex formation. Furthermore, quantum mechanical calculations using PM3 methodology revealed multiple interaction sites with binding distances of 1.7-3.6 Å, involving electrostatic interactions and hydrogen bonding. Subsequently, Box-Behnken experimental design optimization identified optimal conditions: pH 5.6, buffer volume 1.1 mL, erythrosin B concentration 25 µg mL
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