Evidence map›Paper›PMID 42022927›Full record

ReviewJournal of pharmaceutical analysis2026

Polydatin for treating spinal cord injury: Multiple mechanisms and challenges.

Zhishuo Wang, Jiaming Zhang, Longyu Li, Yuhao Zhang, Haoyu Shen, Chunfeng Shang, Zikuan Leng, Guowei Shang, Hongwei Kou, Keya Mao and 3 more

Abstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Journal of pharmaceutical analysis, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Zhishuo WangDepartment of Orthopedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Jiaming ZhangDepartment of Orthopedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Longyu LiDepartment of Orthopedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Yuhao ZhangDepartment of Orthopedics, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing, 102218, China.
Haoyu ShenDepartment of Pediatrics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Chunfeng ShangDepartment of Orthopedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Zikuan LengDepartment of Orthopedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Guowei ShangDepartment of Orthopedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Hongwei KouDepartment of Orthopedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Keya MaoDepartment of Orthopedics, The Chinese PLA General Hospital, Beijing, 100039, China.
Hao HanDepartment of Orthopedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Songfeng ChenDepartment of Orthopedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.
Hongjian LiuDepartment of Orthopedics, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, 450052, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Spinal cord injury (SCI) is a serious neurological system disease. After SCI, a series of cascade reactions can cause irreversible damage, with a high disability rate and mortality rate. The complexity of the pathological mechanism of SCI limits the efficacy of various traditional therapies, and it is urgent to find new therapeutic means. In recent years, the method of extracting effective components from natural Chinese herbs for treating diseases has attracted widespread attention. Polydatin (PD) is an active ingredient extracted from Polygonum cuspidatum and its structure is similar to the traditional drug resveratrol. Sufficient studies have proved that PD plays anti-inflammatory, antioxidant, anti-apoptotic and neuroprotective roles in the treatment of multisystem diseases. These effects are also significant in the treatment of SCI. Based on the structural differences between PD and resveratrol, this paper illustrates the feasibility of PD in the treatment of SCI, and systematically expounds the pathophysiological process of SCI and the molecular mechanism of PD in the treatment of SCI. Furthermore, this article discusses feasible measures to improve the bioavailability of PD, summarizes the application of new drug delivery systems in PD, and analyzes the challenges and prospects of PD in SCI treatment.

Indexed as

Anti-inflammatoryAntioxidative stressNeuroprotectionPolydatinSpinal cord injury

Identifiers

PMID42022927
PMCPMC13098523

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.