Evidence map›Paper›PMID 42022920›Full record

ReviewFrontiers in sports and active living2026

Immersive motor-cognitive virtual reality training for cognitive frailty: a systematic review and meta-analysis of randomized controlled trials.

Sensen Pan, Bo Zheng, Feifei Zhang, Liyan Lin

Abstract readReview
In one paragraph

Review in Frontiers in sports and active living, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Sensen PanDepartment of Rehabilitation, The Second Affiliated Hospital and Yuying Children's Hospital of WMU, Zhejiang, China.
Bo ZhengGlobal Visiting Scholar Program, UNC of Greensboro, Greensboro, NC, United States.
Feifei ZhangDepartment of Rehabilitation, The Second Affiliated Hospital and Yuying Children's Hospital of WMU, Zhejiang, China.
Liyan LinDepartment of Rehabilitation, The Second Affiliated Hospital and Yuying Children's Hospital of WMU, Zhejiang, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Cognitive frailty-defined as the coexistence of physical frailty and mild cognitive impairment without dementia-has gained attention as a potentially reversible condition linked to functional decline, disability, and future dementia. Traditional motor-cognitive or physical training programs can be beneficial, yet they often suffer from low engagement and limited ecological relevance. Immersive virtual reality (VR) has emerged as a promising alternative because it provides interactive, multisensory environments capable of simultaneously stimulating cognitive and motor processes. Although several trials have evaluated VR in older adults with cognitive frailty, the overall effect remains uncertain. Recent meta-analyses have generally been broad in scope, combining heterogeneous populations or non-immersive VR systems, and no review has specifically focused on immersive motor-cognitive VR in individuals formally diagnosed with cognitive frailty. Objective: To evaluate whether immersive motor-cognitive VR improves global cognition and physical frailty in adults with cognitive frailty. Methods: Five databases were searched through March 09, 2026, for randomized controlled trials using immersive or semi-immersive motor-cognitive VR in adults diagnosed with cognitive frailty. Global cognition was the primary outcome and physical frailty the secondary. Pooled effect sizes were calculated using SMDs or MDs with 95% CIs. Risk of bias was assessed with Cochrane criteria, and certainty of evidence with GRADE. Results: Three randomized controlled trials ( Conclusion: Immersive motor-cognitive VR may improve both cognitive function and frailty severity in adults with cognitive frailty. Evidence remains limited by the small number of trials and variation in VR systems and intervention protocols. Larger, high-quality studies are needed to confirm these findings. Systematic Trial Registration: https://www.crd.york.ac.uk/PROSPERO/view/CRD420251234169, PROSPERO database CRD420251234169.

Indexed as

cognitive frailtyimmersive virtual realitymeta-analysisphysical frailtyrandomized controlled trials (RCTs)

Identifiers

PMID42022920
PMCPMC13095833

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.