ArticleInternational journal of women's health2026
HPV Genotypes and Survival Outcomes in Invasive Cervical Cancer: A Retrospective Molecular Analysis of FFPE Clinical Samples in an Iranian Cohort.
Article in International journal of women's health, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- Epidemiology of Human Papillomavirus in the Middle East and North Africa: A Review of Genotypic Prevalence, Vaccination Challenges, and Non-Cervical Clinical Outcomes.Diseases (Basel, Switzerland) · 2026Review
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Authors and funding
7 authors.
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Abstract
Background: High-risk human papillomavirus (HPV) genotypes differ in carcinogenic potential and may be associated with distinct clinical and survival outcomes in invasive cervical cancer. Methods: Tumor DNA was extracted from formalin-fixed paraffin-embedded (FFPE) cervical cancer samples (N = 120). HPV genotyping was then performed using a type-specific molecular assay (SENMURV HPV Genotyping Kit, Stem Cell Technology Co., Iran). The identified genotypes were subsequently grouped for survival analysis (HPV16 alone, HPV16 co-infection, HPV18-containing, and mixed infections with ≥3 types). Clinicopathologic and follow-up data were obtained from medical records, and overall survival was analyzed using Kaplan-Meier estimates and Cox proportional hazards models. Results: Single HPV16 infection was the predominant genotype pattern across the histologic subtypes, whereas HPV18-containing and multiple-genotype infections were less frequent and showed a non-significant trend toward poorer early survival. In multivariable Cox regression analysis, age remained the only independent predictor of overall survival (HR = 1.035; 95% CI: 1.005-1.065; p = 0.020), while histologic subtype and HPV genotype were not statistically significant. Overall, 33 deaths were observed during follow-up in the study cohort. Conclusion: Although no statistically significant associations were observed, HPV genotype-specific patterns suggested potential differences in survival, particularly for HPV18-containing infections. As exploratory, hypothesis-generating findings, these results highlight the need for larger, multicenter cohorts to clarify the independent prognostic role of HPV genotypes alongside established clinical factors.
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