ReviewJournal of extracellular biology2026
The Role of Extracellular Vesicles in Transient Ischaemic Attacks and Ischaemic Stroke: A Systematic Review.
Review in Journal of extracellular biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Stroke is the second leading cause of death and a major contributor of long-term disability globally. Ischaemic stroke (IS) is the most common type of stroke; characterised by a blood clot that causes oxygen deprivation in the brain. Survivors often face long-lasting disabilities, imposing significant social and economic burden. Up to a quarter of IS are preceded by a transient ischaemic attack (TIA), where temporary symptoms occur due to a short-term interruption in blood flow. Currently, there is no reliable method to identify which TIA patients are at greatest risk of stroke. Early identification of circulating biomarkers in this cohort could inform clinical follow-up and help prevent future strokes. Extracellular vesicles (EVs) are membrane bound nanoparticles, released by all cell types playing key roles in cell-to-cell communication. EVs have recently emerged as effective biomarkers in disease diagnostics, yet their involvement in IS and TIA remains poorly understood. To explore this, a systematic review was undertaken following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) Guidelines. A comprehensive search of PubMed, Scopus and Web of Science up to May 2025 yielded 1206 articles, of which 31 met the inclusion criteria and were analysed. This review highlights the necessity for standardised methodologies, particularly in EV isolation and characterisation, to allow data comparability and clarity of the role of EVs in the pathophysiology of IS and TIA.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.