Evidence map›Paper›PMID 42022807›Full record

ArticleFrontiers in cellular and infection microbiology2026

Dysregulated T cell responses and inflammatory cytokine profiles in patients with acute chikungunya fever: a study from Guangdong, 2025.

Mingya Xiao, Zijing Liu, Si Wang, Qian Yi, E-Ying Lu, Ruirong Xu, Wei Li, Yongkui Li, Wenli Li

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Article in Frontiers in cellular and infection microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Mingya Xiao *Department of Infectious Diseases, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China.
Zijing Liu *Department of Immunology and Microbiology, Institute of Medical Microbiology, College of Life Science and Technology, Jinan University, Guangzhou, China.
Si Wang *Department of Immunology and Microbiology, Institute of Medical Microbiology, College of Life Science and Technology, Jinan University, Guangzhou, China.
Qian YiDepartment of Immunology and Microbiology, Institute of Medical Microbiology, College of Life Science and Technology, Jinan University, Guangzhou, China.
E-Ying LuDepartment of Infectious Diseases, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China.
Ruirong XuDepartment of Infectious Diseases, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China.
Wei LiDepartment of Immunology and Microbiology, Institute of Medical Microbiology, College of Life Science and Technology, Jinan University, Guangzhou, China.
Yongkui LiDepartment of Immunology and Microbiology, Institute of Medical Microbiology, College of Life Science and Technology, Jinan University, Guangzhou, China.
Wenli LiDepartment of Infectious Diseases, The Affiliated Guangdong Second Provincial General Hospital of Jinan University, Guangzhou, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Chikungunya fever (CHIKF), an acute arboviral disease caused by the chikungunya virus (CHIKV), is characterized by fever, debilitating arthralgia, and systemic inflammation, posing a significant public health burden in endemic regions like Guangdong Province, China. The early immunopathological mechanisms following CHIKV infection remain incompletely understood. This prospective cohort study investigated dysregulated effector T cell responses and inflammatory cytokine profiles in 34 patients with acute CHIKF, compared to 20 healthy controls, during a 2025 outbreak in Guangdong. Flow cytometry and multiplex cytokine analysis revealed significant suppression of key effector populations, including CD3

Indexed as

Chikungunya FeverCytokinesT-LymphocytesAdultChikungunya virusChinaFemaleHumansInflammationMaleMiddle AgedNatural Killer T-CellsProspective StudiesCytokinesarthralgiachikungunya virusfeverIL-1βinflammatory cytokinesT cell dysregulation

Identifiers

PMID42022807
PMCPMC13095717

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.