Evidence map›Paper›PMID 42022794›Full record

ArticleHuman mutation2026

Single-Cell Sequencing and Mendelian Randomization Reveal T Cell Nuclear Factor Genes in Hepatocellular Carcinoma Progression.

Yunfei Chen, Xiting Yang, Lintao Zhong, Kai Chen, Le Luo

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Human mutation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors.

Yunfei ChenOrgan Transplantation Center, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China, uestc.edu.cn.
Xiting YangHepatobiliary and Pancreatic Surgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China, uestc.edu.cn.
Lintao ZhongSchool of Medical and Life Sciences of Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Kai ChenOrgan Transplantation Center, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China, uestc.edu.cn.ORCID https://orcid.org/0000-0001-6735-0716
Le LuoHepatobiliary and Pancreatic Surgery, Sichuan Provincial People's Hospital, University of Electronic Science and Technology of China, Chengdu, China, uestc.edu.cn.ORCID https://orcid.org/0000-0002-5433-3164

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This study integrates single-cell RNA sequencing with Mendelian randomization to elucidate the role of nuclear factor of activated T cells (NFAT)-related genes in the progression of hepatocellular carcinoma (HCC). The GSE162616 dataset was analyzed to identify differentially expressed cells and NFAT-related genes through quality control, clustering, and

Indexed as

Carcinoma, HepatocellularKiller Cells, NaturalLiver NeoplasmsNFATC Transcription FactorsT-LymphocytesCalcium-Binding ProteinsCell CommunicationCell Cycle ProteinsCTLA-4 AntigenDisease ProgressionHumansMendelian Randomization AnalysisMuscle ProteinsNerve Tissue ProteinsNomogramsSingle-Cell Gene Expression AnalysisCACYBP protein, humanCalcium-Binding ProteinsCell Cycle ProteinsCTLA-4 AntigenCTLA4 protein, humanMuscle ProteinsNerve Tissue ProteinsNFATC Transcription FactorsRGCC protein, humanhepatocellular carcinomahub geneMendelian randomizationnuclear factor of activated T cellssingle-cell

Identifiers

PMID42022794
PMCPMC13096692

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.