Evidence map›Paper›PMID 42022787›Full record

ArticleInfection prevention in practice2026

Investigation and control of a meticillin-resistant

K Thorley, J Foster, S Urquhart, J Swinney, N Q Verlander, E Clissold, M Ganner, Y Ryan, K Moganeradj, T Lamagni and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Infection prevention in practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

K ThorleyHealth Protection in Regions Directorate, UK Health Security Agency, London, UK.
J FosterMid and South Essex NHS Foundation Trust, East of England, Essex, UK.
S UrquhartMid and South Essex NHS Foundation Trust, East of England, Essex, UK.
J SwinneyMid and South Essex NHS Foundation Trust, East of England, Essex, UK.
N Q VerlanderStatistics, Modelling and Economics Department, UK Health Security Agency, London, UK.
E ClissoldRoyal Free London NHS Foundation Trust, London, UK.
M GannerAntimicrobial Resistance and Healthcare Associated Infections Division, UK Health Security Agency, London, UK.
Y RyanAntimicrobial Resistance and Healthcare Associated Infections Division, UK Health Security Agency, London, UK.
K MoganeradjAntimicrobial Resistance and Healthcare Associated Infections Division, UK Health Security Agency, London, UK.
T LamagniAntimicrobial Resistance and Healthcare Associated Infections Division, UK Health Security Agency, London, UK.
E DowlingMid and South Essex NHS Foundation Trust, East of England, Essex, UK.
S KapadiaHealth Protection in Regions Directorate, UK Health Security Agency, London, UK.
E HeinsbroekHealth Protection in Regions Directorate, UK Health Security Agency, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Neonatal unit outbreaks of meticillin-resistant Aim: To describe the outbreak investigations, and risk factors identified through a cohort study. Methods: Cases were neonatal unit inpatients from May to September 2023 with an MRSA-positive sample within the whole-genome sequencing (WGS)-linked outbreak cluster. Concurrent screening of mothers was conducted throughout, along with one-off staff and environmental sampling. Hospital record data for all unit inpatients between May and September were reviewed. A retrospective cohort study was conducted. Findings: Of 84 neonatal unit inpatients, 14 (16.7%) had MRSA colonizations within the WGS-linked cluster. There were two outbreak waves: seven cases in outbreak weeks 1-8, and seven cases in outbreak weeks 16-19. The median time between admission and first MRSA-positive swab was 9.5 days (range 3-24). In univariable analysis, MRSA colonization was associated with lower gestational age, lower birth weight, and having clinical exposures (respiratory support, invasive lines, and gavage or enteral feeding). No association was identified with twin birth, delivery method or cot exposures. Maternal and environmental screening identified no MRSA-positive results. Staff screening identified two outbreak-strain-positive results. Conclusions: This paper describes an outbreak of MRSA colonizations in a neonatal unit in England, and the risk factors for infant colonization, identified by conducting a cohort study. The outbreak, whilst complex, was controlled successfully, with the second outbreak wave guiding implementation of additional control measures, including staff screening.

Indexed as

Healthcare-associated infectionsMRSANeonatesOutbreak

Identifiers

PMID42022787
PMCPMC13098614

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.