ArticleFrontiers in neuroscience2026
A novel clip-based nerve compression model with high stability and reproducibility for the study of chronic nerve injury associated with neuropathic pain.
Article in Frontiers in neuroscience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: The pathogenesis of neuropathic pain (NP) is complex and remains incompletely understood, making it essential to establish animal models that can stably and reproducibly recapitulate pain behaviors and functional impairments. The conventional chronic constriction injury (CCI) model of the sciatic nerve is highly operator dependent, resulting in limited reproducibility. This study aimed to establish a NP model with improved stability and reproducibility. Methods: A NP model was generated by applying sustained and quantifiable mechanical compression to the rat sciatic nerve using a clip device. Pain-related behavioral tests, gait analysis, electrophysiological recordings, and histological and immunofluorescence analyses were conducted to systematically compare and validate the clip-compression model against the CCI model. Results: Quantitative measurements using a thin-film pressure sensor demonstrated that the clip applied a consistent force of 1.75 ± 0.17 N. Behavioral assessments showed that both the CCI and clip-compression models reliably induced pain hypersensitivity; however, the clip-compression model exhibited a more persistent and stable pain phenotype. Gait and electrophysiological evaluations revealed significant ipsilateral hind-limb gait dysfunction, reduced weight-bearing capacity, and impaired peripheral nerve conduction in the clip-compression model. Histological and immunofluorescence analyses indicated that both models caused nerve fascicle disorganization, myelin damage, and axonal degeneration. Notably, the clip-compression model was associated with relatively milder inflammatory cell infiltration, greater early preservation of myelin architecture, and maintained nerve trunk continuity, more closely resembling the pathological features of chronic nerve compression. Conclusion: This study establishes and systematically validates a novel clip-based nerve compression model of NP, providing a more stable, reliable, and reproducible animal model for mechanistic studies and therapeutic evaluation in NP research.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.