ArticleCureus2026
The Role of Preoperative Neutrophil-to-Lymphocyte Ratio and C-reactive Protein in Predicting the Severity of Cholelithiasis With Cholecystitis.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionAcute calculous cholecystitis is a common surgical condition with variable clinical severity. Early identification of severe disease remains challenging. Inflammatory biomarkers such as neutrophil-to-lymphocyte ratio (NLR) and C-reactive protein (CRP) have been proposed as simple indicators of systemic inflammation and disease severity. The present study aimed to evaluate the association of preoperative NLR and CRP levels with the severity of calculous cholecystitis and their relationship with clinical outcomes. MATERIALS AND
methodsThis prospective observational study was conducted over two years in a tertiary care centre and included 48 patients diagnosed with cholelithiasis with cholecystitis and undergoing laparoscopic cholecystectomy. Preoperative NLR and CRP levels were recorded within 24 hours prior to surgery. Based on intraoperative findings and histopathology, patients were classified into simple, purulent, and gangrenous cholecystitis. Correlation analysis was performed to assess the relationship between inflammatory markers and duration of hospital stay.
resultsThe mean age was 45.08 ± 13.78 years, with female predominance 30 (62.5%). Simple cholecystitis was most common 23 (47.9%), followed by purulent 15 (31.3%) and gangrenous 10 (20.8%). Median NLR and CRP were 2.67 and 10.55 mg/dl, respectively. Both NLR and CRP increased significantly with worsening severity (p < 0.001). NLR showed a strong positive correlation with CRP (r = 0.641, p = 0.001). NLR (r = 0.427, p = 0.001) and CRP (r = 0.539, p = 0.001) correlated significantly with longer hospital stay. Age and BMI were not significantly associated with severity.
conclusionPreoperative NLR and CRP levels are significantly associated with the severity of calculous cholecystitis and duration of hospitalization. These readily available biomarkers may serve as useful adjuncts in clinical severity assessment.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.