ArticleNeuroscience insights2026
Mature Schwann Cells Derived From Human Induced Pluripotent Stem Cells Promote Peripheral Nerve Regeneration In Vivo.
Article in Neuroscience insights, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Peripheral nerve injuries (PNIs) often cause persistent sensory and motor deficits that impair quality of life. To improve outcomes, cell-based therapies have been explored, and Schwann cells (SCs) are considered a promising option because of their essential roles in myelination and neurotrophic support. However, the clinical use of autologous SCs is limited by donor site morbidity and challenges in large-scale expansion, leading to growing interest in human induced pluripotent stem cell (iPSC)-derived SCs. This study aimed to verify the therapeutic effects of iPSC-derived SCs in vivo and to determine whether the differentiation stage of the SCs influences their efficacy. We generated dibutyryl-cAMP-treated mature SCs and untreated immature SCs from iPSCs and transplanted them into a rat sciatic nerve crush injury model. Morphometric analysis showed that myelinated fiber density (fibers/mm
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