ArticleFrontiers in nutrition2026
Fermented cotton stalks preserve colonic epithelial integrity in Hu sheep via the microbiota-metabolite-NF-κB/MLCK axis and mitigate the adverse effects of direct feeding.
Article in Frontiers in nutrition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: This study aimed to compare three cotton-stalk processing strategies-grinding (FS), steam explosion (PH), and microbial fermentation (FJ)-and to clarify whether fermented cotton stalks preserve colonic epithelial integrity through a microbiota-metabolite-NF‑κB/MLCK axis in Hu sheep. Methods: Fifteen clinically healthy Hu sheep (26.7 ± 1.76 kg body weight; 115 ± 4 days of age) were used after a 14‑day adaptation period and randomly assigned to one of three diets ( Results: PH and FJ increased final body weight compared with FS, and average daily gain increased progressively from FS to PH to FJ (206.07, 282.50, and 322.14 g/d, respectively; Conclusion: Fermentation‑based processing of cotton stalks enhanced growth performance and promoted a favorable hindgut fermentation and microbial-metabolic milieu, thereby reinforcing colonic barrier integrity via inhibition of NF‑κB/MLCK‑associated inflammatory signaling, supporting fermented cotton stalk as a practical strategy to valorize cotton residues for ruminant feeding while mitigating gossypol‑related hindgut stress.
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