ArticleGastro hep advances2026
Arthritis and High Alcohol Intake at Diagnosis Increase Future Risk of Hepatocellular Carcinoma in
Article in Gastro hep advances, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background and Aims: HFE hemochromatosis (HH) may cause arthritis, cirrhosis, and hepatocellular carcinoma (HCC). Cirrhosis is the main risk factor for HCC in HH. Arthritis is common in HH, strongly associated with cirrhosis and readily diagnosed. Thus, we evaluated whether arthritis might be of clinical utility in predicting the future risk of HCC in HH. Methods: Two hundred four clinically well-characterized patients with HH were recruited between 1974 and 2013 and attended for regular follow-up at a single center over a median duration of 15.2 years. Clinical, biochemical, and cirrhosis status were recorded at diagnosis. The occurrence of HCC was defined as a documented diagnosis in the medical record. Results: Ten of the 204 patients with HH developed HCC during a follow-up; 9 of these had recorded arthritis status. Seven of 88 patients with arthritis at diagnosis of HH subsequently developed HCC compared with 2 of 115 patients without arthritis (relative risk = 4.57, 95% confidence interval (CI) 1.11-19.07, Conclusion: Arthritis combined with higher alcohol consumption at diagnosis of HH is associated with an increased risk of future development of HCC.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.