Evidence map›Paper›PMID 42022517›Full record

ArticleRespirology case reports2026

Idiopathic Multicentric Castleman's Disease Diagnosed by Pulmonary Histopathology: A Case Report.

Yuki Kurihara, Yuta Kishikawa, Mizuki Nanri, Arisa Ibi, Yuki Kuwahara, Tetsuro Haraguchi, Natsuko Komiya, Shinsuke Ogusu, Hiroki Tashiro, Chiho Nakashima and 2 more

Abstract read
In one paragraph

Article in Respirology case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Yuki KuriharaDivision of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine Saga University Saga Japan.ORCID https://orcid.org/0009-0002-5122-6723
Yuta KishikawaDivision of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine Saga University Saga Japan.
Mizuki NanriDivision of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine Saga University Saga Japan.
Arisa IbiDepartment of Pathology Saga University Hospital Saga Japan.
Yuki KuwaharaDivision of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine Saga University Saga Japan.
Tetsuro HaraguchiDivision of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine Saga University Saga Japan.
Natsuko KomiyaDivision of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine Saga University Saga Japan.
Shinsuke OgusuDivision of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine Saga University Saga Japan.
Hiroki TashiroDivision of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine Saga University Saga Japan.ORCID https://orcid.org/0000-0001-9699-414X
Chiho NakashimaDivision of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine Saga University Saga Japan.
Seiichi KatoDepartment of Pathology and Microbiology Faculty of Medicine Saga University Saga Japan.
Koichiro TakahashiDivision of Hematology, Respiratory Medicine and Oncology, Department of Internal Medicine, Faculty of Medicine Saga University Saga Japan.ORCID https://orcid.org/0000-0003-0461-5072

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

A 41-year-old woman who presented with lower back pain, stiff shoulders and fatigue was found to have inflammatory laboratory findings and bilateral ground-glass opacities on chest x-ray. High-resolution computed tomography (HRCT) revealed consolidation, a nodular shadow, multiple mediastinal and hilar lymphadenopathy, liver enlargement, and splenomegaly. Lung biopsy showed lymphoid follicles, plasma cells and lymphocyte infiltration along bronchovascular bundles and interlobular septa, and plasma cells infiltrating the interfollicular area. Lymph node pathology revealed regressed germinal centres and an extended interfollicular area with plasma cell infiltration, as well as capillary proliferation with endothelial hyperplasia. There were no specific findings of lymphoma or immunoglobulin G4 (IgG4)-related disease and she was diagnosed with idiopathic multicentric Castleman's disease (iMCD). According to consensus diagnostic criteria, lymph node pathology is required for diagnosing iMCD, but this case demonstrates that lung lesions may also provide diagnostic supportive value.

Indexed as

high‐resolution computed tomography (HRCT)idiopathic multicentric Castleman's disease (iMCD)lymphadenopathytocilizumabvideo‐assisted thoracoscopic lung biopsy

Identifiers

PMID42022517
PMCPMC13098072

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.