Evidence map›Paper›PMID 42022370›Full record

ArticleClinical and experimental hepatology2025

Does thyroid function disorder play a vital role in the pathogenesis of neonatal cholestasis?

Salma Abdel Megeed Nagi, Mai Ibrahim Elashmawy, Mohamed Zaeim Hafez Ahmed, Mahmoud Ahmad Mohammed Azab, Ashraf AbdelAty Elshenawy Emara, Osama Mohammad Mohammad Abdelhay, Mohamed AbdelAziz Doma, Ahmad Mohamed Mohamed Awad, Ahmed Mohammed Saba, Tarek Shikhon and 4 more

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Article in Clinical and experimental hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

14 authors.

Salma Abdel Megeed NagiFaculty of Medicine, King Salman International University, El Tor Branch, South Sinai, Egypt.
Mai Ibrahim ElashmawyClinical Pathology Department, National Liver Institute, Menoufia University, Shebin El-Kom 32511, Egypt.
Mohamed Zaeim Hafez AhmedMedical Physiology Department, Faculty of Medicine, Al-Azhar University (Assiut), Assiut, Egypt.
Mahmoud Ahmad Mohammed AzabMedical Physiology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Ashraf AbdelAty Elshenawy EmaraMedical Physiology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Osama Mohammad Mohammad AbdelhayMedical Physiology Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Mohamed AbdelAziz DomaMedical Biochemistry Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Ahmad Mohamed Mohamed AwadMedical Biochemistry Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Ahmed Mohammed SabaMedical Biochemistry Department, Faculty of Medicine, Al-Azhar University, Cairo, Egypt.
Tarek ShikhonMedical Biochemistry Department, Faculty of Medicine, Al-Azhar University (Assiut), Assiut, Egypt.
Hesham Abdelrahman Mahmoud AhmedMedical Biochemistry Department, Faculty of Medicine, Al-Azhar University (Assiut), Assiut, Egypt.
Ahmed Mohamed Gad AllahForensic Medicine and Clinical Toxicology Department, Faculty of Medicine, Al-Azhar University (Assiut), Assiut, Egypt.
Marwa Fekry HassanEpidemiology and Preventive Medicine Department, National Liver Institute, Menoufia University, Shebin El Kom, Menoufia, 6132415, Egypt.
Shymaa Sobhy Menshawy KhalifaPediatrics Department, Faculty of Medicine, Menoufia University, Shebin El Kom, Menoufia, 6132415, Egypt.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Neonatal cholestasis is a syndrome characterized by decreased bile flow in infants and has several underlying causes, including genetic and metabolic diseases. Thyroid dysfunction may contribute to the pathophysiology of cholestasis, although it is not often acknowledged as a major cause. Further research into this possible connection is necessary because studies have linked thyroid conditions, including hyperthyroidism and euthyroid sick syndrome, to liver damage in newborns. This study aimed to evaluate the thyroid function in infants with neonatal cholestasis and determine whether it has a role in the diagnosis of other causes of neonatal cholestasis. Material and methods: The study included 100 infants with neonatal cholestasis of different causes (50 infants with biliary atresia [BA] and 50 infants with other causes of neonatal cholestasis other than BA) attending the National Liver Institute, Menoufia University, between July 2024 and January 2025. The infants were evaluated for serum free triiodothyronine (T3), free tetraiodothyronine (T4), and thyroid-stimulating hormone (TSH). Results: T3 was significantly higher in the non-BA group (3.97 ±0.45) than the BA group ( Conclusions: The results demonstrated significant differences in T3 levels, with higher levels observed in the non-BA group, while T4 and TSH showed no significant differences between the two groups. These findings suggest that thyroid dysfunction may be associated with neonatal cholestasis, particularly in conditions other than BA.

Indexed as

biliary atresiahyperthyroidismneonatal cholestasispathogenesisthyroid function

Identifiers

PMID42022370
PMCPMC13097288

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