ArticleClinical and experimental hepatology2025
Ethnic heterogeneity in steatosis-driven liver injury among MASLD patients: Han Chinese vs. Caucasian.
Article in Clinical and experimental hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Aim of the study: Despite the increasing prevalence of metabolic dysfunction-associated steatotic liver disease (MASLD) worldwide, the ethnic differences in clinical features remain unknown. We aimed to compare steatosis-associated liver severity differences between Han Chinese vs. Caucasian patients with MASLD. Material and methods: This was a cross-sectional study comparing Han Chinese MASLD patients from four University-affiliated Medical Centers of fatty liver in south China from January 2015 to January 2023 and Caucasian MASLD patients from the UK Biobank database. All patients were measured for anthropometric parameters, biochemistry markers, metabolic tests and liver fat content (LFC) determined with the magnetic resonance imaging proton density fat fraction (MRI-PDFF). Results: Han Chinese MASLD patients ( Conclusions: Han Chinese MASLD patients tended to suffer from higher risk of high liver fat content associated liver injuries than Caucasian patients, suggesting that higher hepatic lipotoxicity sensitivity compared to Caucasians might be one of the ethnic distinctions of Chinese populations.
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