Evidence map›Paper›PMID 42022292›Full record

ArticleBrain communications2026

Unbiased data-driven analysis of five amyloid-beta peptides for biomarker investigations in familial Alzheimer's disease.

Isaac Llorente-Saguer, Rebecca Gabriele, Teisha Y Bradshaw, Claire A Leckey, Christopher R S Belder, Lucía Chávez-Gutiérrez, Rohan de Silva, Nick C Fox, Selina Wray, Neil P Oxtoby and 1 more

Abstract read
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In one paragraph

Article in Brain communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Isaac Llorente-SaguerDepartment of Medical Physics and Biomedical Engineering and UCL Hawkes Institute, University College London, London WC1V 6LJ, UK.
Rebecca GabrieleDepartment of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK.
Teisha Y BradshawDepartment of Clinical and Movement Neurosciences, Reta Lila Weston Institute, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK.
Claire A LeckeyTranslational Mass Spectrometry Research Group, UCL Great Ormond Street Hospital Institute of Child Health, University College London, London WC1N 1EH, UK.
Christopher R S BelderDementia Research Centre, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK.
Lucía Chávez-GutiérrezVIB-KU Leuven Center for Brain & Disease Research, Leuven 3001, Belgium.
Rohan de SilvaDepartment of Clinical and Movement Neurosciences, Reta Lila Weston Institute, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK.ORCID https://orcid.org/0000-0002-5052-5775
Nick C FoxDepartment of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK.
Selina WrayDepartment of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK.ORCID https://orcid.org/0000-0003-3062-7050
Neil P OxtobyDepartment of Computer Science and UCL Hawkes Institute, University College London, London WC1V 6LJ, UK.ORCID https://orcid.org/0000-0003-0203-3909
Charles ArberDepartment of Neurodegenerative Disease, UCL Queen Square Institute of Neurology, London WC1N 3BG, UK.ORCID https://orcid.org/0000-0002-9743-8134

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Changes to the relative abundance of amyloid-beta (Aβ) peptides are hallmarks of Alzheimer's disease. Induced pluripotent stem cell (iPSC)-derived neurons offer a physiological model of Aβ production. We employed unbiased, data-driven analyses to investigate combinations of Aβ peptides as Alzheimer's disease biomarkers and the relative contribution of peptides to Alzheimer's disease pathogenesis. We measured Aβ37, Aβ38, Aβ40, Aβ42 and Aβ43 in 10 iPSC-neuronal cultures from

Indexed as

Alzheimer’s diseaseamyloidbiomarkerdata-driveniPSC

Identifiers

PMID42022292
PMCPMC13096935

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.