Evidence map›Paper›PMID 42022288›Full record

ArticleFrontiers in molecular biosciences2026

D- and L-lactate dehydrogenase reactions increase pH to lactate production and decrease pH to pyruvate production.

Robert Robergs, Marek Nalos, Petr Kelbich, Adela Jizerová, Ivana Mervartová, Michal Vostrý, Milan Štengl, Vaclav Babuška

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in molecular biosciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Article
  2. HFrontiers in molecular biosciences · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Robert RobergsSchool of Exercise and Nutrition Sciences, Faculty of Health, Queensland University of Technology, Kelvin Grove, QLD, Australia.
Marek NalosDepartment of Physiology, Faculty of Medicine, Charles University, Pilsen, Czechia.
Petr KelbichDepartment of Biomedicine and Laboratory Diagnostics, Faculty of Health Studies, Jan Evangelista Purkyne University, Usti nad Labem, Czechia.
Adela JizerováDepartment of Biomedicine and Laboratory Diagnostics, Faculty of Health Studies, Jan Evangelista Purkyne University, Usti nad Labem, Czechia.
Ivana MervartováFaculty of Environment, Jan Evangelista Purkyne University, Usti nad Labem, Czechia.
Michal VostrýFaculty of Health Studies, Jan Evangelista Purkyne University, Usti nad Labem, Czechia.
Milan ŠtenglDepartment of Physiology, Faculty of Medicine, Charles University, Pilsen, Czechia.
Vaclav BabuškaDepartment of Medical Chemistry and Biochemistry, Faculty of Medicine, Charles University, Pilsen, Czechia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: The traditional explanation of metabolic acidosis in extrahepatic tissues is the increased cellular production of lactic acid. We tested whether the LDH reaction produces lactate and pyruvate anions, or acids, and measured the pH changes that occur for either direction of the reaction. Methods: Results: The H Conclusion: Scientists and clinicians are encouraged to use these results to further understand the function of the LDH reaction during perturbations of pH in biological systems.

Indexed as

acidosisalkalosisenzyme catalysismetabolismspectrophotometry

Identifiers

PMID42022288
PMCPMC13095559

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.