ReviewFrontiers in molecular biosciences2026
GPCR systems coordinate cellular resilience against aging-associated stress.
Review in Frontiers in molecular biosciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- GPCR signaling systems facilitate precision interventions for multi-oncology therapy.Frontiers in systems biology · 2026Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aging-related diseases arise from cumulative cellular damage driven by diverse stressors. G protein-coupled receptors (GPCRs) play a critical role in coordinating cellular resilience to these stressors. We propose that stable multiprotein GPCR complexes-termed "receptorsomes"-function as adaptive hubs that sense, integrate, and mitigate stress across subcellular compartments. Receptorsomes comprise a GPCR core non-covalently associated with specific adaptors (e.g., β-arrestins, GIT2, RGS proteins, ASK1, YAP/TAZ), enabling pluridimensional, G protein-independent signaling that balances stress detection, damage repair, and homeostasis. This review synthesizes evidence linking receptosome composition to responses against oxidative, proteostatic, hypoxic, and other stressors, mapping these to aging hallmarks. We hypothesize that therapeutically tuning receptorsome adaptor engagement could enhance resilience, delay pathology, and extend health span, offering predictions for future testing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.