ArticleJournal of inflammation research2026
The Relationship Between Decreased Serum Klotho Protein and Cognitive Impairment in Patients After Abdominal Surgery.
Article in Journal of inflammation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Postoperative cognitive dysfunction (POCD) is a common complication in elderly patients undergoing abdominal surgery; however, reliable biomarkers for its early identification are limited. Klotho, an anti-aging protein with neuroprotective and anti-inflammatory properties, may play a role in POCD development. This study investigated the association between serum Klotho levels and POCD, as well as their relationships with inflammation and cognitive outcomes. Methods: A total of 93 patients undergoing abdominal surgery were enrolled and classified into non-POCD (n = 59) and POCD (n = 34) groups based on their postoperative Montreal Cognitive Assessment (MoCA) scores. Serum Klotho, C-reactive protein (CRP), interleukin (IL)-1β, and IL-6 levels were measured preoperatively and postoperatively. Multivariate logistic regression, receiver operating characteristic (ROC) curve analysis, and Pearson correlation analyses were performed to evaluate associations and predictive value. Results: Patients who developed POCD had significantly longer durations of anesthesia than those without POCD (all Conclusion: Decreased postoperative serum Klotho levels are closely associated with increased inflammation and cognitive impairment following abdominal surgery. Klotho may serve as a promising biomarker for the early identification of POCD and as a potential therapeutic target to improve postoperative cognitive outcomes.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.