Multistep coevolution of HIV-1 and human leukocyte antigen-C-restricted HIV-1-specific CD8

Takayuki Chikata, Tomohiro Akahoshi, Yu Zhang, Hung The Nguyen, Shinichi Oka, Hiroyuki Gatanaga, Masafumi Takiguchi

Abstract read

In one paragraph

Article in PNAS nexus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Takayuki ChikataDivision of International Collaboration Research and Tokyo Laboratory, Joint Research Center for Human Retrovirus Infection, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan.ORCID https://orcid.org/0000-0001-8907-1320

Tomohiro AkahoshiDivision of International Collaboration Research and Tokyo Laboratory, Joint Research Center for Human Retrovirus Infection, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan.ORCID https://orcid.org/0009-0004-6604-3684

Yu ZhangDivision of International Collaboration Research and Tokyo Laboratory, Joint Research Center for Human Retrovirus Infection, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan.

Hung The NguyenDivision of International Collaboration Research and Tokyo Laboratory, Joint Research Center for Human Retrovirus Infection, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan.ORCID https://orcid.org/0000-0003-0053-0274

Shinichi OkaAIDS Clinical Center, National Center for Global Health and Medicine, Japan Institute for Health Security, Tokyo 162-8655, Japan.

Hiroyuki GatanagaAIDS Clinical Center, National Center for Global Health and Medicine, Japan Institute for Health Security, Tokyo 162-8655, Japan.ORCID https://orcid.org/0000-0001-9191-9984

Masafumi TakiguchiDivision of International Collaboration Research and Tokyo Laboratory, Joint Research Center for Human Retrovirus Infection, Kumamoto University, 2-2-1 Honjo, Chuo-ku, Kumamoto 860-0811, Japan.ORCID https://orcid.org/0000-0002-8516-6442

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Disease progression during HIV-1 infection is proposed to correlate with the accumulation of virus variants that have evaded HIV-1-specific T cells; however, the multistep coevolution of HIV-1 with HIV-1-specific T cells has not been well investigated. Here, we analyzed the coevolution of HIV-1 with human leukocyte antigen (HLA)-C*14-restricted HIV-1-specific T cells in treatment-naive HLA-C*14

Indexed as

coevolutionHIV-1HLA-CmutationT cell

Identifiers

PMID42022213

DOI10.1093/pnasnexus/pgag105

PMCPMC13096738

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.