Evidence map›Paper›PMID 42022198›Full record

ArticleEnvironment & health (Washington, D.C.)2026

Metabolic Reprogramming Bridges Environmental Exposure and Tinnitus Severity: Evidence from AI-Driven Serum Multiomics.

Tingting Qian, Ge Wang, Peifan Li, Nanfeng Zhang, Chongkai Lu, Yongzhen Wu, Xia Gao, Yi-Quan Tang, Huawei Li, Shan Sun

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Environment & health (Washington, D.C.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Tingting QianENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Shanghai Key Laboratory of Gene Editing and Cell Therapy for Rare Diseases, NHC Key Laboratory of Hearing Medicine Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China.
Ge WangENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Shanghai Key Laboratory of Gene Editing and Cell Therapy for Rare Diseases, NHC Key Laboratory of Hearing Medicine Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China.
Peifan LiENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Shanghai Key Laboratory of Gene Editing and Cell Therapy for Rare Diseases, NHC Key Laboratory of Hearing Medicine Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China.
Nanfeng ZhangDepartment of Otolaryngology Head and Neck Surgery, Jiangsu Provincial Key Medical Discipline (Laboratory), Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China.
Chongkai LuENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Shanghai Key Laboratory of Gene Editing and Cell Therapy for Rare Diseases, NHC Key Laboratory of Hearing Medicine Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China.
Yongzhen WuENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Shanghai Key Laboratory of Gene Editing and Cell Therapy for Rare Diseases, NHC Key Laboratory of Hearing Medicine Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China.
Xia GaoDepartment of Otolaryngology Head and Neck Surgery, Jiangsu Provincial Key Medical Discipline (Laboratory), Nanjing Drum Tower Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing 210008, China.ORCID https://orcid.org/0000-0002-4539-5929
Yi-Quan TangENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Shanghai Key Laboratory of Gene Editing and Cell Therapy for Rare Diseases, NHC Key Laboratory of Hearing Medicine Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China.
Huawei LiENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Shanghai Key Laboratory of Gene Editing and Cell Therapy for Rare Diseases, NHC Key Laboratory of Hearing Medicine Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China.
Shan SunENT Institute and Department of Otorhinolaryngology, Eye & ENT Hospital, Shanghai Key Laboratory of Gene Editing and Cell Therapy for Rare Diseases, NHC Key Laboratory of Hearing Medicine Research, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Fudan University, Shanghai 200032, China.ORCID https://orcid.org/0000-0003-2142-4307

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Tinnitus is a prevalent auditory disorder with poorly understood links between environmental exposure and disease, complicating objective diagnosis and intervention. In a graded observational cohort with documented occupational noise histories, we integrated serum metabolomics, lipidomics, and immunophenotyping with interpretable machine learning. Mediation analysis suggested that a panel of metabolites, including gamma-aminobutyric acid (GABA), fumaric acid, and sphingolipids, accounted for a substantial proportion of the association between noise exposure and tinnitus severity (indirect effect = 92%,

Indexed as

biomarkersenvironmental exposureGABAmachine learningmultiomicsneuroinflammationsphingolipidstinnitus

Identifiers

PMID42022198
PMCPMC13097159

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.