ArticleEnvironment & health (Washington, D.C.)2026
Association between Gestational Nitrated Polycyclic Aromatic Hydrocarbons Exposure Burden and Newborn Sizes: Mediating the Role of Placental 8‑OHdG.
Article in Environment & health (Washington, D.C.), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Nitrated polycyclic aromatic hydrocarbons (nitro-PAHs) are persistent pollutants accompanying air pollution. No research has reported their exposure burden in pregnant women, nor is there epidemiological evidence of associations with newborn size. In this study, we recruited 947 mother-infant pairs from China. A morning spot urine sample was collected to measure the concentration of five nitro-PAHs exposure biomarkers using liquid chromatography tandem mass spectrometry. Three of five measured amino-PAHs were detected in over 50% of the population, and the concentration was 0.044, 0.268, and 0.103 ng/mg creatinine for 1-AP, 2-AF, and 9-APhe, respectively. Using generalized linear regression, we found per ln unit increase in the concentration of 1-AP which was significantly associated with reduced newborn weight Z-Score (-0.12 [-0.20, -0.03]), length Z-Score (-0.11 [-0.17, -0.05]), and weight-for-length Z-Score (-0.09 [-0.16, -0.01]), respectively. The mixture effect model showed a negative association between mixed nitro-PAHs exposure and length Z-Score and weight Z-Score, with 1-AP being the dominant contributor to the effect. To explore how maternal nitro-PAHs exert impact on the developing fetus, the potential mediating role of placental 8-hydroxy-2'-deoxyguanosine (8-OHdG), a classical biomarker of DNA oxidative damage, was measured in a subset of samples (
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