Evidence map›Paper›PMID 42022172›Full record

ArticleIJU case reports2026

Durable Disease Control With Nivolumab in Malignant Epithelioid Angiomyolipoma: A Case Report.

Hiroki Shimoda, Shohei Fukuda, Daiki Yafuso, Kouhei Yamamoto, Yudai Ishikawa, Hiroshi Fukushima, Yuma Waseda, Hajime Tanaka, Soichiro Yoshida, Yasuhisa Fujii

Abstract read
In one paragraph

Article in IJU case reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Hiroki ShimodaDepartment of Urology Institute of Science Tokyo Tokyo Japan.
Shohei FukudaDepartment of Urology Institute of Science Tokyo Tokyo Japan.ORCID https://orcid.org/0000-0003-2741-8338
Daiki YafusoDepartment of Human Pathology Institute of Science Tokyo Tokyo Japan.
Kouhei YamamotoDepartment of Human Pathology Institute of Science Tokyo Tokyo Japan.
Yudai IshikawaDepartment of Urology Institute of Science Tokyo Tokyo Japan.ORCID https://orcid.org/0000-0001-7118-5522
Hiroshi FukushimaDepartment of Urology Institute of Science Tokyo Tokyo Japan.
Yuma WasedaDepartment of Urology Institute of Science Tokyo Tokyo Japan.
Hajime TanakaDepartment of Urology Institute of Science Tokyo Tokyo Japan.ORCID https://orcid.org/0000-0003-3632-2901
Soichiro YoshidaDepartment of Urology Institute of Science Tokyo Tokyo Japan.ORCID https://orcid.org/0000-0003-2757-8083
Yasuhisa FujiiDepartment of Urology Institute of Science Tokyo Tokyo Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Introduction: Epithelioid angiomyolipoma is a subtype of perivascular epithelioid cell tumors that may exhibit malignant behavior. While mammalian target of rapamycin inhibitors are commonly used for systemic treatment, the efficacy of immune checkpoint inhibitors remains unclear. Case Presentation: A 58-year-old man was diagnosed with epithelioid angiomyolipoma after partial nephrectomy of a right renal mass. The tumor recurred locally, and multiple lung metastases developed despite surgical resection. Nivolumab was initiated after disease progression on everolimus, resulting in durable disease control for over 3 years. Immunohistochemistry revealed high PD-L1 expression and CD8+ T-cell infiltration within the primary tumor. Conclusion: Immune checkpoint inhibitors may be effective treatment options for malignant epithelioid angiomyolipoma with PD-L1 expression and CD8+ T-cell infiltration.

Indexed as

CD8epithelioid angiomyolipomaimmune checkpoint inhibitorperivascular epithelioid cell tumorsprogrammed death ligand 1

Identifiers

PMID42022172
PMCPMC13097437

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.