ArticleFrontiers in bioengineering and biotechnology2026
The antimicrobial peptide EM86 loaded to gamma-irradiated sodium alginate/polyvinyl alcohol electrospun nanofibrous dressing treated multidrug-resistant
Article in Frontiers in bioengineering and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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Who cites it
1 citing paper in PubMed.
- A Comprehensive Review of Antimicrobial Peptides and Smart Biomaterials in Chronic Wound Therapy: Overcoming Biofilms, Resistance, and Translational Barriers.International journal of molecular sciences · 2026Review
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Authors and funding
6 authors.
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Abstract
Background: Treating infected wounds is challenging, and conventional dressings delay healing. Resistance to the last-resort antibiotics is on the rise. Antimicrobial peptides (AMPs) offer advantages over traditional antibiotics against multidrug-resistant (MDR) bacterial strains. We aimed to use a computer-aided approach to design an anti-Gram-negative AMP with reduced mammalian cell toxicity and to functionalize an electrospun nanofibrous dressing with the AMP for Methods: Colistin and polymyxin sequences were modified to generate analogs using a template-based approach. The membrane activity was predicted using the collection of antimicrobial peptide database. Three shortlisted sequences were synthesized, and their minimum inhibitory concentrations (MICs) and minimum bactericidal concentrations (MBCs) against MDR Gram-negative bacterial isolates were determined. The time-kill kinetics of the potent candidate against Results: EM86 exhibited bactericidal activity against all tested isolates. EM86 killed Conclusion: Using computer-aided approaches, we designed EM86 with a bactericidal activity against MDR Gram-negative microorganisms and reduced toxicity to HSF compared to colistin. EM86-functionalized SA/PVA nanofibrous dressings offer a better treatment alternative for colistin-resistant infections in open wounds.
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