ArticleEFSA journal. European Food Safety Authority2026
Safety and efficacy of a feed additive consisting of difructose anhydride III (NITTEN DFA III) for female bovines, ovines, caprines in the periparturient period and neonates fed colostrum and milk/milk replacer in early life (Nippon Beet Sugar Manufacturing Co., Ltd).
Article in EFSA journal. European Food Safety Authority, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- Safety and efficacy of a feed additive consisting of difructose anhydride III (NITTEN DFA III) for female bovines, ovines, caprines in the periparturient period and neonates fed colostrum and milk/milk replacer in early life (Nippon Beet Sugar Manufacturing Co., Ltd).EFSA journal. European Food Safety Authority · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
23 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Following a request from the European Commission, EFSA was asked to deliver a scientific opinion on the safety and efficacy of difructose anhydride III as a zootechnical feed additive (functional group: physiological condition stabilisers) for neonatal and female adult bovines, caprines and ovines. Based on tolerance studies in calves and periparturient cows, the Panel on Additives and Products or Substances used in Animal Feed concluded that the additive is considered safe for the target species within the scope of application. The use of difructose anhydride III in animal nutrition is not of concern for consumer or environmental safety under the proposed conditions of use. The additive is not an eye or skin irritant. Due to the lack of data, the Panel could not conclude on the dermal sensitisation of the additive. The Panel concluded that the additive has the potential to act as a zootechnical additive to increase the serum concentration of IgG in calves when supplemented at 54 g/calf (colostrum) on day 1 and 36 g/calf (milk replacer) from days 2 to 7, and in other neonatal bovines, caprines and ovines when used up to 7 days at similar levels. The Panel noted that these levels exceed those specified in the conditions of use and are not supported by the safety data. No conclusion could be reached on the efficacy of the additive on the serum Ca and Mg concentration or milk production when used in feed for adult female bovines, caprines and ovines.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.