ArticleFrontiers in microbiology2026
Postbiotics from lactic acid bacteria as promising alternatives against urinary tract pathogens.
Article in Frontiers in microbiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
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6 authors.
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Abstract
Urinary tract infections (UTIs) are one of the most common bacterial infections in hospital settings and are increasingly difficult to treat due to the rise of antibiotic-resistant uropathogens (UP). Therefore, exploring alternatives to antibiotic therapy is crucial to control the spread of these pathogens. Lactic acid bacteria (LAB) have demonstrated broad antimicrobial activity against various microorganisms, and postbiotics, bioactive compounds derived from these probiotic bacteria, are emerging as a promising tool for controlling such infections. In this study, several LAB strains exhibited antagonistic activity against different clinical UP isolates. To assess whether this activity was due to secreted metabolites, cell-free supernatants (CFSs) were obtained from 24 h LAB cultures. CFSs exhibited variable antimicrobial activity against most UP isolates. Notably, these inhibitory effects were completely lost after pH neutralization and partially reduced by heat or protease treatment, suggesting the involvement of organic acids and/or proteinaceous molecules. CFSs were able to inhibit biofilm formation and partially disrupt mature biofilms of
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