ArticleAlzheimer's & dementia (Amsterdam, Netherlands)
Quantitative assessment of brain atrophy in bvFTD: Implications for diagnostic conversion.
Article in Alzheimer's & dementia (Amsterdam, Netherlands). The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.
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Who cites it
2 citing papers in PubMed.
- Hybrid multimodal late fusion frameworks for bvFTD classification in imbalanced dementia datasets.Frontiers in aging neuroscience · 2026Article
- Quantitative assessment of brain atrophy in bvFTD: Implications for diagnostic conversion.Alzheimer's & dementia (Amsterdam, Netherlands)Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionBrain atrophy increases diagnostic confidence in behavioral variant frontotemporal dementia (bvFTD); however, standardized tools have not been systematically applied. This study evaluated visual rating scales (VRS) to quantify atrophy in a longitudinal bvFTD cohort with differing diagnostic certainties.
methodsNinety-three probable and 15 possible bvFTD patients were recruited. Five validated VRS were applied to magnetic resonance imaging scans by blinded raters. Receiver operating characteristic curves and logistic regression examined baseline differentiation and predictors of probable bvFTD. Longitudinal analyses and qualitative case review assessed VRS as predictors of diagnostic conversion.
resultsBilateral orbitofrontal and frontoinsular atrophy differentiated probable from possible bvFTD (areas under the curve > 0.7). Baseline left orbitofrontal VRS strongly predicted baseline probable bvFTD (odds ratio = 3.77, DISCUSSION: VRS enhance diagnostic certainty and may assist in monitoring bvFTD disease progression across clinical settings.
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