Evidence map›Paper›PMID 42022046›Full record

ArticleOphthalmology science2026

Fundus Autofluorescence as a Sensitive Biomarker of Disease Progression in Bietti Crystalline Dystrophy.

Huanyu Zhao, Masatoshi Fukushima, Takahiro Hisai, Yan Tao, Sakurako Shimokawa, Kaho Yamamoto, Yoshito Koyanagi, Koh-Hei Sonoda, Takaaki Hayashi, Shinji Ueno and 5 more

Abstract read
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In one paragraph

Article in Ophthalmology science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Huanyu ZhaoDepartment of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Masatoshi FukushimaDepartment of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Takahiro HisaiDepartment of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Yan TaoDepartment of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Sakurako ShimokawaDepartment of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Kaho YamamotoDepartment of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Yoshito KoyanagiDepartment of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Koh-Hei SonodaDepartment of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Takaaki HayashiDepartment of Ophthalmology, The Jikei University School of Medicine, Tokyo, Japan.
Shinji UenoDepartment of Ophthalmology, Graduate School of Medicine, Hirosaki University, Hirosaki, Japan.
Manabu MiyataDepartment of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, Japan.
Kaoru FujinamiDivision of Vision Research, National Institute of Sensory Organs, NHO Tokyo Medical Center, Tokyo, Japan.
Kazushige TsunodaDivision of Vision Research, National Institute of Sensory Organs, NHO Tokyo Medical Center, Tokyo, Japan.
Akio OishiDepartment of Ophthalmology and Visual Sciences, Graduate School of Biomedical Sciences, Nagasaki University, Nagasaki, Japan.
Yusuke MurakamiDepartment of Ophthalmology, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To characterize the natural history of Bietti crystalline dystrophy (BCD) and to identify reliable outcome measures for detecting disease progression. Design: A multicenter, prospective observational study. Participants: Patients with genetically confirmed BCD carrying biallelic pathogenic Methods: Multimodal imaging and functional assessments included BCVA, static perimetry (Humphrey 10-2), fundus autofluorescence, and OCT. Main Outcome Measures: Longitudinal changes in BCVA; hypo-autofluorescent (hypo-AF) area; and static perimetry parameters, such as mean deviation (MD), absolute scotoma points (ASPs), transitional zone retinal sensitivity (TZRS), and central subfield thickness (CST). Results: Thirteen patients with genetically confirmed BCD were followed prospectively over a median of 2.5 years (range: 2.5-3 years). Longitudinal analysis showed progression in hypo-AF area (12.0 mm Conclusions: This prospective natural history study suggests that hypo-AF area may serve as a useful structural measure for detecting disease progression in BCD clinical trials, warranting further validation in larger prospective studies. Financial Disclosures: Proprietary or commercial disclosure may be found in the Footnotes and Disclosures at the end of this article.

Indexed as

Bietti crystalline dystrophy (BCD)BiomarkerDisease progressionFundus autofluorescence (FAF)Hypo autofluorescent area

Identifiers

PMID42022046
PMCPMC13096951

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.