ArticleClinical and experimental hepatology2025
Associations between diffusion-weighted imaging and immunohistochemical features in hepatocellular carcinoma: a preliminary analysis of tumor-infiltrating lymphocytes and microvessel density expression.
Article in Clinical and experimental hepatology, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Imaging modalities can predict histopathological characteristics of tumors such as cellularity and proliferation potential, which has also been shown for hepatocellular carcinoma (HCC). Diffusion-weighted imaging can reflect cellularity of tumors and provide apparent diffusion coefficient (ADC) values as a quantitative imaging marker. This analysis elucidates possible associations between ADC values and several immunohistochemical features of HCC. Material and methods: A cohort of 25 patients (4 female; 16%) with a mean age of 63 ±8.9 years met the inclusion criteria of this analysis. The main inclusion criteria were the availability of an MRI pre-interventional examination within 9 months before surgery and the availability of the histopathologic analysis. Immunohistochemical features included programmed cell death-ligand 1 (PD-L1) scores (immune cell score [ICS], tumor proportion score [TPS], and combined positive score [CPS]), glypican-3, tumor-infiltrating lymphocytes (TIL), stroma infiltrating lymphocytes (SIL), CD68 positive cells and microvessel density (MVD). ADC values were measured as ADC Results: CD3+ TIL showed a moderate inverse correlation with ADC Conclusions: The present analysis demonstrated an inverse correlation between CD3-positive tumor-infiltrating lymphocytes and ADC
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