Evidence map›Paper›PMID 42021982›Full record

ArticleFood technology and biotechnology

Modulating Complex Secondary Metabolism in

Martina Avbelj, Lucija Slemc, Alen Pšeničnik, Špela Zver, Anastasija Lazova, Kristina Mervič, Khan Mohammad Sarim, Maja Paš, Antonio Starčević, Martin Šala and 3 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Food technology and biotechnology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Martina AvbeljFood Science and Technology Department, Biotechnical Faculty, University of Ljubljana, 1000 Ljubljana, Slovenia.ORCID https://orcid.org/0000-0001-8677-2332
Lucija SlemcFood Science and Technology Department, Biotechnical Faculty, University of Ljubljana, 1000 Ljubljana, Slovenia.ORCID https://orcid.org/0000-0002-8868-734X
Alen PšeničnikFood Science and Technology Department, Biotechnical Faculty, University of Ljubljana, 1000 Ljubljana, Slovenia.ORCID https://orcid.org/0000-0001-5375-2220
Špela ZverFood Science and Technology Department, Biotechnical Faculty, University of Ljubljana, 1000 Ljubljana, Slovenia.
Anastasija LazovaFood Science and Technology Department, Biotechnical Faculty, University of Ljubljana, 1000 Ljubljana, Slovenia.
Kristina MervičDepartment of Analytical Chemistry, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia.ORCID https://orcid.org/0009-0006-5000-3201
Khan Mohammad SarimDivision for Physical Chemistry, Ruđer Bošković Institute, 10000 Zagreb, Croatia.
Maja PašFood Science and Technology Department, Biotechnical Faculty, University of Ljubljana, 1000 Ljubljana, Slovenia.
Antonio StarčevićFaculty of Food Technology and Biotechnology, University of Zagreb, 10000 Zagreb, Croatia.ORCID https://orcid.org/0000-0003-2386-2124
Martin ŠalaDepartment of Analytical Chemistry, National Institute of Chemistry, Hajdrihova 19, 1000 Ljubljana, Slovenia.ORCID https://orcid.org/0000-0001-7845-860X
Miha TomeFood Science and Technology Department, Biotechnical Faculty, University of Ljubljana, 1000 Ljubljana, Slovenia.ORCID https://orcid.org/0000-0001-7729-7381
Dušica VujaklijaDivision for Physical Chemistry, Ruđer Bošković Institute, 10000 Zagreb, Croatia.ORCID https://orcid.org/0000-0003-1184-1828
Hrvoje PetkovićFood Science and Technology Department, Biotechnical Faculty, University of Ljubljana, 1000 Ljubljana, Slovenia.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Research background: Numerous biosynthetic gene clusters (BGCs) encoding unknown structures have been discovered in the genomes of diverse microorganisms, representing a potentially rich source of novel natural products. However, most of the identified BGCs do not seem to be active, since we cannot detect any corresponding metabolites. Therefore, a better understanding of the regulation and biosynthesis of secondary metabolites encoded by these so-called 'silent' BGCs is of great importance. Experimental approach: We conducted a bioinformatic analysis of the Results and conclusions: We identified 48 BGCs in the genome of Novelty and scientific contribution: We observed that the expression strength of genes from BGCs identified in

Indexed as

biosynthetic gene clustergene regulationgenome reductionoxytetracyclinerimocidin

Identifiers

PMID42021982
PMCPMC13098539

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.