ReviewFrontiers in cell and developmental biology2026
pH/ROS-responsive smart hydrogels for infection control and immune microenvironment modulation in chronic wound healing.
Review in Frontiers in cell and developmental biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
6 citing papers in PubMed.
- Next-generation smart polymeric hydrogels for chronic wound management: integrating antimicrobial, immunomodulatory and regenerative strategies.RSC advances · 2026Review
- Biomedical Hydrogels Based on Oxidized Hyaluronic Acid and Carboxymethyl Chitosan Coordinated with Magnesium Ions.Biomimetics (Basel, Switzerland) · 2026Article
- Bioactive Hydrogel-MOF Composites as Resistance-Modulating Wound Interfaces: Molecular Mechanisms and Rational Design for Chronic Wound Management.Gels (Basel, Switzerland) · 2026Review
- Structure-Function Engineering of Hydrogel-MOF Polymer Composites for Regenerative Wound Dressings with Emerging Antiviral Biointerface Functions.Gels (Basel, Switzerland) · 2026Review
- A Comprehensive Review of Antimicrobial Peptides and Smart Biomaterials in Chronic Wound Therapy: Overcoming Biofilms, Resistance, and Translational Barriers.International journal of molecular sciences · 2026Review
- Periprosthetic Joint Infection: Biofilm Pathogenesis, Immune Dysregulation, and Emerging Prosthetic Interface Strategies.Biology · 2026Review
Corrections and comments
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Authors and funding
6 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Chronic wounds are characterized by persistent infection, excessive oxidative stress, and dysregulated inflammation, which together hinder tissue repair and promote non-healing states. In this context, pH/ROS-responsive hydrogels have emerged as promising smart wound-dressing platforms because they can exploit local acidic and oxidative cues for site-specific structural change, controlled cargo release, and microenvironment-adaptive therapy. This review summarizes the pathological basis for pH/ROS-responsive intervention and discusses recent advances in hydrogel design for infection control, ROS scavenging, and immune microenvironment modulation. We further highlight key translational challenges, including manufacturing complexity, degradation-product safety, storage stability, and the limitations of current preclinical models. Overall, pH/ROS-responsive hydrogels represent a promising strategy for chronic wound management, but future progress will depend on achieving a better balance between multifunctional performance and translational practicality.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.