ReviewToxicology reports2026
Regulatory integration of new approach methodologies for human-relevant developmental and reproductive toxicity (DART) assessment: A systematic cross-sector review.
Review in Toxicology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
1 citing paper in PubMed.
- From toxicogenomics to predictive toxicology and exposomics: defining the next decade of gene-environment research.Frontiers in genetics · 2026Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Developmental and reproductive toxicity (DART) assessment is a critical component of regulatory safety evaluation across pharmaceutical, chemical, environmental, and consumer product sectors. Traditionally, DART testing has relied on animal-based studies designed to detect adverse effects on fertility, embryonic development, and postnatal growth. However, these conventional approaches present increasing scientific and ethical challenges, including high costs, extended study durations, limited mechanistic insight, and interspecies differences that may reduce their predictive value for human health outcomes. Concurrently, regulatory frameworks increasingly emphasize the principles of Replacement, Reduction, and Refinement (3Rs), driving the development of alternative testing strategies. This systematic review examines the evolving regulatory landscape for DART assessment and evaluates the scientific and regulatory progress associated with emerging New Approach Methodologies (NAMs). A structured literature search was conducted across major scientific databases following PRISMA 2020 guidelines, identifying relevant scientific and regulatory publications from
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.