ReviewSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition2026
[Research Progress of Peripheral Immune Tolerance in Oral Diseases].
Review in Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Peripheral immune tolerance serves as a core mechanism for maintaining immune homeostasis within the body. Regulatory T cells (Tregs) are the key cells responsible for performing this function. Through cell-contact-dependent mechanisms, secretion of inhibitory cytokines, and metabolic interference, Tregs actively suppress the activation of effector immune cells. In the local oral environment, the dynamic balance of the Treg/T helper cell 17 (Th17) axis is of crucial importance for maintaining oral health and represents a common immunopathological basis for various oral diseases. In periodontitis, the excessive activation of Th17 cells and the suppression of Treg function trigger chronic destructive inflammation and alveolar bone resorption. In mucosal diseases such as oral lichen planus and recurrent aphthous ulcers, the disorder of the Treg/Th17 axis results in pathological autoimmune attacks. In oral squamous cell carcinoma, the tumor microenvironment recruits Tregs to establish abnormal immune tolerance, which mediates immune escape and promotes tumor progression. Based on these findings, therapeutic strategies targeting the precise regulation of Treg function or the reshaping of the Treg/Th17 balance are emerging, including cytokine modulators, small molecule drugs, and engineered Treg cell therapies. However, current research continues to encounter bottlenecks, including the unclear mechanism of Tregs heterogeneity and the challenge of achieving both high targeting efficiency and safety in clinical translation. In the future, it is essential to integrate multi-omics technologies to comprehensively analyze the immune regulatory network within the oral microenvironment and develop precise delivery systems to facilitate clinical translation. This article conducts a systematic review of the mechanism of peripheral immune tolerance and the role of Tregs in oral diseases, thoroughly analyzes the characteristics of immune dysregulation in different diseases, and deliberates on the therapeutic strategies based on immune tolerance regulation and their clinical application prospects, aiming to provide a theoretical foundation for precise immune therapy of oral diseases.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.