Evidence map›Paper›PMID 42021887›Full record

ArticleSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition2026

[Mechanism Study of Aconitase 1 Promoting Hepatocellular Carcinoma Growth via the Itaconic Acid-Autophagy Axis].

Sinan Lü, Yurong Yang, Kun Jiang, Chi Cheng, Kui Wang, Changlong Li

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Sinan Lü（ 610041）Department of Biochemistry and Molecular Biology, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, China.ORCID 0000-0002-0907-6912
Yurong Yang（ 610041）Department of Biochemistry and Molecular Biology, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, China.
Kun Jiang（ 610041）Department of Biochemistry and Molecular Biology, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, China.
Chi Cheng（ 610041）Department of Biochemistry and Molecular Biology, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, China.
Kui Wang（ 610041）Department of Biochemistry and Molecular Biology, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, China.
Changlong Li（ 610041）Department of Biochemistry and Molecular Biology, West China School of Basic Medical Sciences and Forensic Medicine, Sichuan University, Chengdu 610041, China.ORCID 0009-0009-0699-0731

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate the expression level of aconitate decarboxylase 1 (ACOD1) in hepatocellular carcinoma (HCC) and its role in HCC cell growth, as well as the underlying mechanisms. Methods: The expression of the Results: ACOD1 protein expression was significantly overexpressed in HCC tissues than in adjacent tissues (approximately 2-fold). Patients with ACOD1 overexpression had shorter overall survival ( Conclusion: ACOD1 is overexpressed in HCC and its' overexpression is associated with poor prognosis. ACOD1 promotes HCC cell growth by synthesizing itaconate, which inhibits cellular autophagy.

Indexed as

AutophagyCarboxy-LyasesCarcinoma, HepatocellularLiver NeoplasmsSuccinatesCell Line, TumorCell ProliferationHep G2 CellsHumansACOD1 protein, humanCarboxy-Lyasesitaconic acidSuccinatesAutophagyCarcinoma ACOD1HepatocellularItaconic acidPrognosis

Identifiers

PMID42021887
PMCPMC13095728

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.