Evidence map›Paper›PMID 42021880›Full record

ArticleSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition2026

[Construction and Efficacy Evaluation of a Highly Efficient Diagnostic Model for Neurosyphilis Driven by the Cerebrospinal Fluid/Serum Free Light Chain Index].

Jielun Deng, Sirui Wu, Fei Ye, Xiyue Huang, Dongdong Li, Jinbo Liu

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

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4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Jielun Deng（ 646000）Department of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.ORCID 0009-0003-4854-5587
Sirui Wu（ 646000）Department of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.
Fei Ye（ 646000）Department of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.
Xiyue Huang（ 646000）Department of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.
Dongdong Li（ 646000）Department of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.
Jinbo Liu（ 646000）Department of Laboratory Medicine, The Affiliated Hospital of Southwest Medical University, Luzhou 646000, China.ORCID 0000-0001-9042-2829

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To determine free light chains (FLC) in cerebrospinal fluid (CSF) and serum, calculate the FLC index, and establish a model to evaluate its application value in diagnosing neurosyphilis. Methods: This study included 87 syphilis patients, comprising 48 neurosyphilis patients (NS group) and 39 non-neurosyphilis patients (n-NS group). CSF and serum samples were collected from all patients to measure kappa free light chains (FLC-κ) and lambda free light chains (FLC-λ). The FLC index, FLC-κ index, and FLC-λ index were calculated. Receiver operating characteristic (ROC) curves were used to evaluate these indices. A neurosyphilis diagnostic model based on the FLC index was established and its visualization was verified. Results: Statistically significant differences were observed between the two groups in serological syphilis screening, CSF nucleated cell count, CSF microprotein, CSF IgG, IgG synthesis rate, IgG index, and albumin quotient ( Conclusion: FLC-κ and FLC-λ have high diagnostic performance for neurosyphilis, and the FLC index has certain application value in the diagnosis of neurosyphilis.

Indexed as

Immunoglobulin kappa-ChainsImmunoglobulin lambda-ChainsImmunoglobulin Light ChainsNeurosyphilisAdultFemaleHumansMaleMiddle AgedImmunoglobulin kappa-ChainsImmunoglobulin lambda-ChainsImmunoglobulin Light ChainsDiagnostic modelFree light chains indexKappa free light chainsLambda free light chainsNeurosyphilis

Identifiers

PMID42021880
PMCPMC13095775

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.