Evidence map›Paper›PMID 42021878›Full record

ArticleSichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition2026

[Protein Expression Levels of the DCAF4-MEN1-hTERT Axis in Patients With Colon Adenocarcinoma and Their Relationship With Clinicopathological Characteristics and Prognosis].

Shun Zhu, Siyuan Chen, Qin Zheng, Hong Liu

Abstract readEnglish Abstract
PubMed Full text at PMC Publisher
In one paragraph

Article in Sichuan da xue xue bao. Yi xue ban = Journal of Sichuan University. Medical science edition, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

4 authors.

Shun Zhu（ 610041）Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.ORCID 0009-0004-5354-5810
Siyuan Chen（ 610041）Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
Qin Zheng（ 610041）Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.
Hong Liu（ 610041）Department of Laboratory Medicine, West China Hospital, Sichuan University, Chengdu 610041, China.ORCID 0000-0001-7311-9086

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To explore the relationship between the expression levels of DNA damage binding protein 1 and cullin 4-related factor 4 (DCAF4) complex, which degrades the tumor suppressor menin 1 (MEN1)-human telomerase reverse transcriptase (hTERT) axis protein, and the clinicopathological characteristics and prognosis of patients with colon adenocarcinoma. Methods: Ninety-four patients with colon adenocarcinoma were included. The expression of DCAF4, MEN1, and hTERT in cancer tissues and adjacent tissues was detected by immunohistochemistry. The expression levels of DCAF4, MEN1, and hTERT in patients with different pathological grades and T stages were compared. Spearman rank correlation was used for correlation analysis, and survival analysis was conducted to investigate the impact of DCAF4, MEN1, and hTERT expression levels on the overall survival of patients with colon adenocarcinoma. Results: The expression levels of DCAF4 and MEN1 proteins in cancer tissues of colon adenocarcinoma patients (10.83 ± 2.89; 9.71 ± 3.57) were higher than those in adjacent tissues (2.39 ± 1.57; 4.92 ± 2.71, Conclusion: High expression of DCAF4 and hTERT, as well as low expression of MEN1, is associated with unfavorable clinical and pathological features but has no significant relationship with prognosis.

Indexed as

AdenocarcinomaColonic NeoplasmsProto-Oncogene ProteinsTelomeraseAdultAgedFemaleHumansMaleMiddle AgedPrognosisProto-Oncogene ProteinsTelomeraseTERT protein, humanClinicopathological characteristicsColonic adenocarcinomaDNA damage-binding protein 1 and cullin 4-associated factor 4 (DCAF4)Human telomerase reverse transcriptase (hTERT)Overall survivalTumor suppressor menin 1 (MEN1)

Identifiers

PMID42021878
PMCPMC13095818

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.