ReviewMedical journal of the Islamic Republic of Iran2025
Sex-related Differences in Health Related Quality of Life Among Hemodialysis Patients: A Systematic Review and Meta Analysis.
Review in Medical journal of the Islamic Republic of Iran, 2025. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Authors and funding
3 authors.
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Abstract
Background: Health-related quality of life (HRQoL) is a key patient-centered outcome in hemodialysis (HD) care, but sex-related differences remain poorly quantified. This systematic review and meta-analysis are focused on comparing HRQoL scores between female and male HD patients across generic (SF-36) and kidney-specific (KDQOL-SF) domains. Methods: This systematic review and meta-analysis followed PRISMA 2020 guidelines and was registered in PROSPERO (CRD420251078233). PubMed, Cochrane Library, Embase, and Google Scholar were searched for observational studies reporting HRQoL by sex in adult HD patients published from January 2000 to June 2025. Two reviewers independently screened studies, extracted data, and assessed risk of bias. Mean differences (Females-Males) were pooled using REML random-effects models (95% CI), heterogeneity was quantified using I² and the Q-test, and small-study bias was evaluated using funnel plots and Egger's regression. Results: Nineteen studies (N=6025; 2713 female, 3312 males) were included. In SF-36 domains, females scored lower than males across all eight scales, most notably in Bodily Pain ( Conclusion: Female HD patients consistently experience poorer HRQoL than males across multiple SF-36 and select KDQOL domains. These findings highlight the need for sex-sensitive interventions, such as tailored pain management and psychosocial support, to improve quality of life in females receiving HD.
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