Evidence map›Paper›PMID 42021788›Full record

ArticleClinical neurophysiology practice2026

Hippocampal interictal discharges induce frontal spindles and enhance spindle-slow oscillation coupling in temporal lobe epilepsy.

Taira Uehara, Ela Austria Barcelon, Hiroshi Shigeto, Takahiko Mukaino, Toshiki Okadome, Nobutaka Mukae, Ayumi Sakata, Hiroyuki Murai, Shozo Tobimatsu, Noriko Isobe and 1 more

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Article in Clinical neurophysiology practice, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Taira UeharaDepartment of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Ela Austria BarcelonDepartment of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Hiroshi ShigetoDepartment of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Takahiko MukainoDepartment of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Toshiki OkadomeDepartment of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Nobutaka MukaeDepartment of Neurosurgery, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Ayumi SakataDivision of Medical Technology, Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Hiroyuki MuraiDepartment of Neurology, International University of Health and Welfare, Narita, Japan.
Shozo TobimatsuDepartment of Clinical Neurophysiology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Noriko IsobeDepartment of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Jun-Ichi KiraDepartment of Neurology, Neurological Institute, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Objective: To investigate how hippocampal interictal epileptiform discharges (IEDs) influence cortical spindles, slow oscillations (SOs), and spindle-SO coupling, which are key components of sleep-dependent memory consolidation. Methods: Simultaneous intracranial and scalp EEG was recorded during NREM sleep in 10 patients with temporal lobe epilepsy (TLE). Hippocampal IEDs were identified using depth electrodes, while spindles and SOs were detected from ipsilateral scalp EEG in frontal, central, parietal, and temporal regions. Peri-IED time histograms and spectral analyses were performed to evaluate the temporal associations between IEDs and the oscillatory events. Spindle-SO coupling was assessed using phase consistency and amplitude modulation metrics. Results: Spindle occurrence increased in the frontal region 0.4-0.8 s after IEDs. This increase occurred regardless of their coincidence with SOs. The incidence of SOs increased within ± 0.4 s of IEDs across regions. Spectral analysis confirmed elevated frontal spindle-band power following IEDs. Phase consistency and amplitude modulation of spindle-SO coupling were higher for IED-coupled than for uncoupled spindles in the frontal region. Conclusions: Hippocampal IEDs selectively induced frontal spindles and enhanced their coupling with SOs. Significance: These findings suggest that IEDs may alter physiological hippocampal-cortical communication relevant to memory consolidation in TLE.

Indexed as

accelerated long-term forgettingFocal epilepsymemory consolidationmemory impairmentsleep spindle

Identifiers

PMID42021788
PMCPMC13098343

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