ArticleFrontiers in neurology
Accuracy of indocyanine green videoangiography in predicting visual outcomes for anterior skull base surgeries, compared to intraoperative visual evoked potential: a pilot explorative study.
Article in Frontiers in neurology. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Introduction: Preserving the microcirculation of the optic nerve (ON) during surgical decompression is crucial, yet there is no dependable intraoperative predictor of visual outcomes. This study examines the use of indocyanine green videoangiography (ICG-VA) as a potential predictor, comparing its effectiveness with intraoperative visual evoked potential (VEP). Methods: We analyzed 13 patients with various perichiasmatic pathologies. Each underwent enhanced MRI, CT scans, detailed ophthalmological examinations, and VEP. Five control patients were included, presumed to have normal pial support post-aneurysmal clipping. Indocyanine green (ICG) was administered at 0.2 mg/kg via peripheral venous access after a rapid injection of 10 mL of 0.9% NaCl before and after tumor resection, using flow analysis software (Flow 800, Carl Zeiss Co.). We meticulously measured the intervals for ICG's appearance in the internal carotid artery (ICA) and the pial circulation of the optic nerve as well as the full saturation of both before and after resection. Results: The study included 13 patients and 5 controls (mean age: cases 55.30 ± 15.2 years; controls 57.8 ± 2.38, Conclusion: ICG-VA of the optic nerve is a promising modality for predicting visual outcomes compared with VEP. Moreover, it could provide more details on the ON vasculature, which would help preserve it during tumor resection. However, additional research, including randomized trials and data, is required to establish a significant difference.
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