Evidence map›Paper›PMID 42021739›Full record

ArticleCirculation research2026

Endothelial NOX1 Drives Obesity via Skeletal Muscle Mitochondrial Dysfunction.

Kai Huang, Yuanli Huang, Yuhan Zhang, Yixuan Zhang, Nicholas W Hatch, Julie K Freed, Hua Cai

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Kai Huang *Division of Molecular Medicine, Department of Anesthesiology and Perioperative Medicine, Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (K.H., Y.H., Yuhan Zhang, Yixuan Zhang, N.W.H., H.C.).
Yuanli Huang *Division of Molecular Medicine, Department of Anesthesiology and Perioperative Medicine, Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (K.H., Y.H., Yuhan Zhang, Yixuan Zhang, N.W.H., H.C.).
Yuhan ZhangDivision of Molecular Medicine, Department of Anesthesiology and Perioperative Medicine, Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (K.H., Y.H., Yuhan Zhang, Yixuan Zhang, N.W.H., H.C.).ORCID 0009-0004-3328-2400
Yixuan ZhangDivision of Molecular Medicine, Department of Anesthesiology and Perioperative Medicine, Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (K.H., Y.H., Yuhan Zhang, Yixuan Zhang, N.W.H., H.C.).
Nicholas W HatchDivision of Molecular Medicine, Department of Anesthesiology and Perioperative Medicine, Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (K.H., Y.H., Yuhan Zhang, Yixuan Zhang, N.W.H., H.C.).
Julie K FreedDepartment of Anesthesiology, Medical College of Wisconsin, Milwaukee (J.K.F.).ORCID 0000-0002-9367-2281
Hua CaiDivision of Molecular Medicine, Department of Anesthesiology and Perioperative Medicine, Division of Cardiology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles (K.H., Y.H., Yuhan Zhang, Yixuan Zhang, N.W.H., H.C.).ORCID 0000-0001-8747-6156

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPresently, we investigated hypothesized roles and mechanisms of cell type-specific, selective activation of different vascular NOX (NADPH oxidase) isoforms in obesity and metabolic syndrome.

methodsWild-type, NOX1/2/4 global knockout mice, endothelial/VSMC-specific NOX1 knockout mice, or vascular endothelial-speicifc NOX1 knockin mice were exposed to high-fat diet feeding prior to phenotypical analyses of obesity and metabolic syndrome, as well as of exercise capacity, skeletal muscle mitochondrial function, and novel genetic signatures.

resultsExpression of NOX1 was significantly upregulated in wild-type mice fed a high-fat diet. Global knockout of NOX1 (NOX1

conclusionsTaken together, our data for the first time establish a novel and paradigm-shifting concept that endothelial NOX1 drives systematic metabolic phenotypes, via impairment in skeletal muscle mitochondrial dysfunction with novel genetic signatures. Tissue-specific targeting of endothelial NOX1 and novel candidate genes may prove to be robustly effective in treating obesity and metabolic syndrome.

Indexed as

Mitochondria, MuscleMuscle, SkeletalNADPH Oxidase 1ObesityAnimalsDiet, High-FatMaleMiceMice, Inbred C57BLMice, KnockoutNADPH Oxidase 1NOX1 protein, mousemetabolic syndromemitochondrial diseasesmuscle, skeletalNADPH oxidasesobesityreactive oxygen species

Identifiers

PMID42021739
PMCPMC13189385

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.