ArticleBrain and behavior2026
Association Between Visceral Adipose Tissue and Depression Risk With Both Observational and Genetic Evidence.
Article in Brain and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
backgroundPrevious studies have demonstrated a link between visceral obesity and depression. Nevertheless, there is a lack of sufficient studies examining the relationship between visceral adipose tissue volume (VATV) and depression, particularly concerning the combined influence of physical activity on this connection.
methodsThe study analyzed data from the National Health and Nutrition Examination Survey cycles spanning 2011-2018. A total of 7460 individuals aged between 20 and 59 years were included. VATV was evaluated using either dual-energy x-ray absorptiometry or magnetic resonance imaging. Multivariate logistic regression models were applied to investigate the relationship between VATV and depression. Mendelian randomization analysis was carried out to examine potential causal relationships.
resultsIn the fully adjusted multivariate logistic regression model, a significant positive association was found between VATV and depression (OR, 1.04; 95% CI, 1.01-1.07). Lower VATV levels combined with effective physical activity significantly reduced depression prevalence. Mendelian randomization analysis identified a causal relationship between VATV and depression.
conclusionsOur study highlights a positive association between visceral fat and depression. Furthermore, participants who regularly engage in physical activity and have low VATV levels are more strongly associated with a reduced prevalence of depression. Importantly, the causal association between them was confirmed. These findings underscore the potential of managing visceral fat to prevent depression.
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