ArticleBrain and behavior2026
Association of Systemic Inflammation Response Index With All-Cause and Cardiovascular Mortality Among Individuals With Depression: NHANES 2005-2018.
Article in Brain and behavior, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe Systemic Inflammation Response Index (SIRI) has recently been investigated as a new marker of inflammation. This study investigated the association between SIRI and all-cause and cardiovascular mortality risks in patients with depression.
methodsBased on data from the National Health and Nutrition Examination Survey (NHANES), 2410 participants with depression were included and followed up for all-cause and cardiovascular-related deaths through December 31, 2019. Depression was identified as a 9-item Patient Health Questionnaire (PHQ-9) score ≥10. Weighted multivariate Cox proportional hazards regression analyses assessed the relationship between SIRI and all-cause and cardiovascular mortality. Time-dependent receiver operating characteristic (ROC) curve analysis evaluated SIRI's accuracy in predicting survival outcomes.
resultsAmong the 2410 participants, 282 all-cause death events and 84 cardiovascular disease (CVD)-related death events were documented. In the fully adjusted models, the highest SIRI tertile was significantly associated with increased risk of all-cause and cardiovascular mortality with hazard ratios (HRs) (95% CIs) of 1.26 (0.79, 2.02) for all-cause mortality and 2.50 (1.22, 5.13) for cardiovascular mortality. This association remained consistent in subgroup and sensitivity analyses. The time-dependent ROC curve showed that the areas under the curve of the 3-, 5-, and 10-year survival rates were 0.702, 0.692, and 0.644 for all-cause mortality, and 0.685, 0.714, and 0.653 for cardiovascular mortality, respectively.
conclusionAn elevated SIRI is associated with an increased risk of all-cause and cardiovascular mortality among patients with depression.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.