Evidence map›Paper›PMID 42021385›Full record

ArticleJournal of animal science and biotechnology2026

Histone lactylation maintains bovine early embryo development via regulating embryonic genome activation.

Wenjie Yu, Yi Xia, Wenzhuo Wang, Zhiyuan Yang, Zhengqiu Liu, Xinqi Gan, Mengya Zhang, Beibei Zhou, Yunsheng Li, Yunhai Zhang and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of animal science and biotechnology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Wenjie Yu *Anhui Province Key Laboratory of Local Livestock and Poultry, Genetical Resource Conservation and Germplasm Innovation, College of Animal Science and Technology, Anhui Agricultural University, No.130 West Changjiang Road, Hefei, 230036, China.
Yi Xia *Anhui Province Key Laboratory of Local Livestock and Poultry, Genetical Resource Conservation and Germplasm Innovation, College of Animal Science and Technology, Anhui Agricultural University, No.130 West Changjiang Road, Hefei, 230036, China.
Wenzhuo WangAnhui Province Key Laboratory of Local Livestock and Poultry, Genetical Resource Conservation and Germplasm Innovation, College of Animal Science and Technology, Anhui Agricultural University, No.130 West Changjiang Road, Hefei, 230036, China.
Zhiyuan YangAnhui Province Key Laboratory of Local Livestock and Poultry, Genetical Resource Conservation and Germplasm Innovation, College of Animal Science and Technology, Anhui Agricultural University, No.130 West Changjiang Road, Hefei, 230036, China.
Zhengqiu LiuAnhui Province Key Laboratory of Local Livestock and Poultry, Genetical Resource Conservation and Germplasm Innovation, College of Animal Science and Technology, Anhui Agricultural University, No.130 West Changjiang Road, Hefei, 230036, China.
Xinqi GanAnhui Province Key Laboratory of Local Livestock and Poultry, Genetical Resource Conservation and Germplasm Innovation, College of Animal Science and Technology, Anhui Agricultural University, No.130 West Changjiang Road, Hefei, 230036, China.
Mengya ZhangAnhui Province Key Laboratory of Local Livestock and Poultry, Genetical Resource Conservation and Germplasm Innovation, College of Animal Science and Technology, Anhui Agricultural University, No.130 West Changjiang Road, Hefei, 230036, China.
Beibei ZhouAnhui Province Key Laboratory of Local Livestock and Poultry, Genetical Resource Conservation and Germplasm Innovation, College of Animal Science and Technology, Anhui Agricultural University, No.130 West Changjiang Road, Hefei, 230036, China.
Yunsheng LiAnhui Province Key Laboratory of Local Livestock and Poultry, Genetical Resource Conservation and Germplasm Innovation, College of Animal Science and Technology, Anhui Agricultural University, No.130 West Changjiang Road, Hefei, 230036, China.
Yunhai ZhangAnhui Province Key Laboratory of Local Livestock and Poultry, Genetical Resource Conservation and Germplasm Innovation, College of Animal Science and Technology, Anhui Agricultural University, No.130 West Changjiang Road, Hefei, 230036, China. yunhaizhang@ahau.edu.cn.
Zubing CaoAnhui Province Key Laboratory of Local Livestock and Poultry, Genetical Resource Conservation and Germplasm Innovation, College of Animal Science and Technology, Anhui Agricultural University, No.130 West Changjiang Road, Hefei, 230036, China. zubingcao@ahau.edu.cn.

Funding

Anhui Province Higher Education Institutions Scientific Research Project Scientific Research Projects of Universities in Anhui 2024AH040078Anhui Provincial Science and Technology Commissioner Project 202513b10050016National Key Research & Developmental Program of China 2023YFD1300502-1Open Project of State Key Laboratory of Animal Biotech Breeding 2025SKLAB6-14Startup Foundation for High-level Talents of Anhui Agricultural University rc392504
6 · The paper itself

Abstract

backgroundEarly embryo loss is an important factor affecting the reproductive capacity of cattle. Recent studies have revealed that during the process of embryonic genome activation (EGA), epigenetic modification, such as histone lactylation remodeling, is crucial for early embryonic development. However, the effects of histone lactylation on early embryonic development in bovines and the related mechanisms remain unknown. In this study, in vitro fertilized embryos were utilized to investigate the effects of histone lactylation on EGA and early embryo development in cattle.

resultsHistone lactylation, including pan-lysine lactylation, histone H3 lysine 9 lactylation, and histone H3 lysine 18 lactylation, occurred mainly in the nucleus and significantly decreased from the 8-cell stage to the morula stage and increased from the morula stage to the blastocyst stage. Decreased or increased levels of histone lactylation induced by GSKA or sodium lactate supplementation inhibited early bovine embryo development and blastocyst lineage differentiation. Furthermore, single-cell RNA sequencing data and 5-ethynyluridine staining revealed that a reduction in histone lactylation levels altered the expression of genes associated with DNA transcription and RNA polymerase activity, thereby impairing EGA. Importantly, β-nicotinamide mononucleotide rescued the inhibitory effects of GSKA supplementation on bovine EGA and early embryonic development.

conclusionsHistone lactylation maintains early bovine embryo development by regulating EGA. Our findings provide a theoretical reference for addressing early embryo loss and thereby increasing the reproductive capacity of cattle.

Indexed as

CattleEmbryonic genome activationHistone lactylationIn vitro fertilization

Identifiers

PMID42021385
PMCPMC13104507

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.