Evidence map›Paper›PMID 42021350›Full record

Trial reportCritical care (London, England)2026

Alternative net ultrafiltration rate strategies in acute kidney injury: a feasibility randomized clinical trial.

Raghavan Murugan, Victor Talisa, Chung-Chou H Chang, Nasrin Nikravangolsefid, Waryaam Singh, Brad W Butcher, Ali Al-Khafaji, Scott Gunn, Firas Abdulmajeed, Phillip Lamberty and 4 more

Abstract readRandomized Controlled TrialMulticenter Study
In one paragraph

Trial report in Critical care (London, England), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Raghavan MuruganThe Program for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America. muruganr@upmc.edu.ORCID http://orcid.org/0000-0002-6823-6365
Victor TalisaThe Center for Research, Investigation, and Systems Modeling of Acute Illness (CRISMA), Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.ORCID http://orcid.org/0000-0001-5246-0349
Chung-Chou H ChangThe Center for Research, Investigation, and Systems Modeling of Acute Illness (CRISMA), Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.ORCID http://orcid.org/0000-0003-3665-6928
Nasrin NikravangolsefidDivision of Nephrology and Hypertension, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, Minnesota, United States of America.
Waryaam SinghDivision of Nephrology and Hypertension, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, Minnesota, United States of America.
Brad W ButcherDepartment of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.ORCID http://orcid.org/0000-0002-4295-5724
Ali Al-KhafajiDepartment of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.
Scott GunnDepartment of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.
Firas AbdulmajeedDepartment of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.
Phillip LambertyDivision of Pulmonary, Allergy, Critical Care, and Sleep Medicine, Department of Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.
David HuangThe Center for Research, Investigation, and Systems Modeling of Acute Illness (CRISMA), Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.ORCID http://orcid.org/0000-0001-7649-1633
Paul M PalevskyThe Program for Critical Care Nephrology, Department of Critical Care Medicine, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania, United States of America.ORCID http://orcid.org/0000-0002-7334-5400
Kianoush KashaniDivision of Nephrology and Hypertension, Division of Pulmonary and Critical Care Medicine, Department of Medicine, Mayo Clinic, Rochester, Minnesota, United States of America.ORCID http://orcid.org/0000-0003-2184-3683
Restrictive versus Liberal Rate of Extracorporeal Volume Removal Evaluation in Acute Kidney Injury (RELIEVE-AKI) Study Investigators

Funding

REstrictive versus LIberal rate of Extracorporeal Volume removal Evaluation in Acute Kidney Injury (RELIEVE-AKI)R01DK128100 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI KASHANI, KIANOUSH B, MURUGAN, RAGHAVAN · 2021 to 2023
$965k
NIDDK NIH HHS R01 DK128100NIDDK NIH HHS R01DK128100
6 · The paper itself

Abstract

Observational studies link high net ultrafiltration (UF

Indexed as

Acute Kidney InjuryContinuous Renal Replacement TherapyAgedFeasibility StudiesFemaleHumansIntensive Care UnitsMaleMiddle AgedUltrafiltrationAcute kidney injuryContinuous kidney replacement therapyFeasibilityNet fluid removalNet ultrafiltrationUltrafiltration rate

Identifiers

PMID42021350
PMCPMC13141483

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.